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  • 1 - Introduction to Biopharmaceutical Processes

  • David Pfister, Lucrèce Nicoud, Massachusetts Institute of Technology, Massimo Morbidelli, Eidgenössische Technische Hochschule Zürich
  • Book:
    Continuous Biopharmaceutical Processes
    Published online:
    22 September 2018
    Print publication:
    11 October 2018, pp 1-26
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  • Summary

    This chapter provides a general introduction on biopharmaceutical processes. The first part presents a brief description of the single unit operations typically encountered during the manufacturing process, including cell culture, purification, viral inactivation, formulation. The second part addresses the potential benefits of continuous technologies in the biopharmaceutical industry both for the upstream and downstream parts of the process, focusing on perfusion bioreactors and continuous counter-current chromatographic processes, respectively. The chapter finishes with a discussion on process integration.