Combinations of thifensulfuron with carbaryl, chlorpyrifos, malathion, and methomyl caused soybean injury that exceeded the expected injury based on effects of herbicide and synergists applied alone. Thifensulfuron-induced injury and growth reductions generally increased as insecticide rates increased from 140 to 560 g ai ha-1. TBPT and fenarimol also synergistically enhanced thifensulfuron injury in soybeans. Yellow foxtail control by thifensulfuron was enhanced slightly by all insecticides except carbaryl. Insecticides did not enhance kochia control by thifensulfuron.