The possibility that Sitophilus zeamais Motschulsky prefers a particular grain side and a grain side area for feeding, and the implications and value in maize programmes' breeding for resistance were investigated in the laboratory at ambient temperature (32.7 °C) and relative humidity (70.4%) using standard techniques. A total of 20 elite maize varieties were used: TZBRCOMP.2C1F1, TZBRELD3C5, PVASYN-3F2, PVASYN-6F2, DTSYN-11-W, BR9943DMRSR, IWDC3SNY-W, WHITEDTSTRSYN, 2008DTMA-YSTR and 2000SYNEE-WSTR, obtained from the Maize Breeding Unit of International Institute for Tropical Agriculture (IITA), Ibadan, Nigeria, and ILE-1-OB, IFEMAIZEHYBRID-1, IFEMAIZEHYBRID-2, IFEMAIZEHYBRID-5, IFEMAIZEHYBRID-6, ARTCOMPOSITE-A-Y, ARTCOMPOSITE-B-Y, ART/98/SW1-OB, ART/98/SW4-OB and ART/98/SW5-OB, obtained from the Institute of Agricultural Research and Training (IAR&T), Moor Plantation, Ibadan, Nigeria. The flat side of a maize grain at the point of penetration was significantly preferred (P≤ 0.05), possibly because it provided much needed space for anchorage and feeding. The South locus of the flattened side of a maize grain was also significantly preferred (P≤ 0.05), possibly because of its soft nature and proximity to the nutrient-rich embryo. The findings of the study have implications for seed viability and can be considered in breeding for resistance to infestation by S. zeamais in stored maize.