We consider the problem of estimating the probability that the maximum of a Gaussian process with negative mean and indexed by positive integers reaches a high level, say b. In great generality such a probability converges to 0 exponentially fast in a power of b. Under mild assumptions on the marginal distributions of the process and no assumption on the correlation structure, we develop an importance sampling procedure, called the target bridge sampler (TBS), which takes a polynomial (in b) number of function evaluations to achieve a small relative error. The procedure also yields samples of the underlying process conditioned on hitting b in finite time. In addition, we apply our method to the problem of estimating the tail of the maximum of a superposition of a large number, n, of independent Gaussian sources. In this situation TBS achieves a prescribed relative error with a bounded number of function evaluations as n ↗ ∞. A remarkable feature of TBS is that it is not based on exponential changes of measure. Our numerical experiments validate the performance indicated by our theoretical findings.