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  • 9 - Basic science: eggs and ovaries

  • from SECTION 2 - BASIC SCIENCE OF REPRODUCTIVE AGEING
  • Edited by Susan Bewley, William Ledger, University of New South Wales, Sydney, Dimitrios Nikolaou
  • Book:
    Reproductive Ageing
    Published online:
    05 February 2014
    Print publication:
    01 June 2009, pp 89-94

  • Summary

    This chapter presents a discussion between experts on eggs and ovaries. There is no genetic condition in humans which seems to be associated with a long-time rescue of primordial follicles. Sixty seems to be pretty close to the limit, maybe very exceptionally beyond that. Eggs or ovarian tissue can be frozen. The central role that signalling pathway plays in cell growth throughout the body is indisputable, which actually limits what we might be able achieve in an oocyte. But there are molecules that suppress the destruction of FOXO. An aspect is some fascinating data in mice suggest that nutrition has a major impact on the rate at which oocytes are lost from the ovary. Certainly, reproductive lifespan and functional lifespan of the ovary can be prolonged by calorie restriction. Real clock genes operate in oocytes that intrinsically regulate the rate at which the follicles start to grow and become atretic.