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  • 3 - Understanding the Pharmacology and Physiology of Cannabis Dependence

  • from Part I - The Nature of Cannabis Dependence
  • Edited by Roger Roffman, University of Washington, Robert S. Stephens, Virginia College of Technology
  • Foreword by G. Alan Marlatt, University of Washington
  • Book:
    Cannabis Dependence
    Published online:
    29 October 2009
    Print publication:
    23 February 2006, pp 37-57

  • Summary

    This chapter summarizes several important advances of the actions of cannabis and its interaction with an endogenous cannabinoid system. The subsequent discovery of cannabinoid binding sites and the cloning of two cannabinoid receptor subtypes provide definitive support for the existence of cannabinoid receptors. The existence of an endocannabinoid system in the central nervous system has gained general acceptance as a result of the discovery of both endogenous cannabinoids and cannabinoid receptors. More recently, chronic marijuana use has been associated with an increased risk of cannabis dependence. Studies of drug self-administration in animals have proved valuable in elucidating the mechanisms of action underlying drug-reinforced behavior as well as predicting the abuse liability of new drugs. Evidence is also beginning to emerge suggesting that opioid receptors may play a modulatory role on cannabinoid dependence.