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2 results

  • The role of inflammation in pathogenesis of juvenile schizophrenia

  • S. Zozulya, M. Omelchenko, I. Otman, A. Yakimets, Z. Sarmanova, V. Kaleda, T. Klyushnik
  • Journal:
    European Psychiatry / Volume 64 / Issue S1 / April 2021
    Published online by Cambridge University Press:
    13 August 2021, pp. S764-S765
    • Article
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  • Introduction

    Inflammation is now known to be a key factor in the development of schizophrenia. In this regard, the study of the pathogenic role of inflammation in the early stages of schizophrenic process is of particular importance, making it possible to assess its activity and to predict the development of the disease.

    Objectives

    To compare the dynamics of inflammatory markers in blood of first-episode psychosis (FEP) patients and people at risk signs for schizophrenia in the course of the treatment. Juvenile depression (JD) with attenuated symptoms of schizophrenic spectrum (ASSS) was investigated as a risk group.

    Methods

    The patients aged 17-25 years (20 people, of which 10 FEP patients (F20) and 10 JD with ASSS ones (F32.1-2, F32.38, F32.8)) were examined at admission to the hospital and at discharge. The controls consisted of 10 healthy volunteers. Symptom severity was collected using PANSS, SOPS, SANS, HDRS. The inflammation markers (TNF-α, IL-6, IL-10, leukocyte elastase (LE), CRP, α1-proteinase inhibitor (α1-PI), anti-S100-beta antibodies) were determined in blood.

    Results

    An increase of inflammatory markers in both groups compared to controls was found (p<0,05). The highest values of IL-6, LE, CRP, α1-PI and anti-S100-beta antibodies in FEP patients were revealed (p=0,03). After the treatment, the positive trend of inflammatory markers in FEP patients (p<0,05), but not in JD with ASSS patients was detected (except LE activity, p<0,05).

    Conclusions

    The results confirm the pathogenic role of inflammation in the development of endogenous mental disorders. The inflammatory markers studied reflect the activity of the pathological process in the early stages of schizophrenia.

    Disclosure

    No significant relationships.

  • 13 - Natural history of mood disorders in children and adolescents

  • Edited by Ian M. Goodyer, University of Cambridge
  • Book:
    The Depressed Child and Adolescent
    Published online:
    18 December 2009
    Print publication:
    11 January 2001, pp 353-381

  • Summary

    Knowledge of the natural history of an illness is critical to understanding its origins and to optimizing its management. Over the past 15 years, data have been accumulating steadily on the course and outcome of juvenile affective conditions. This chapter begins with an account on the risk of recurrence of juvenile depression. This is followed by the mechanisms involved in continuity and recurrence. Prospects for recovery and the natural history of other juvenile affective disorders are discussed with a focus on bipolar disorder. Finally, a discussion of some of the clinical implications of these research findings is presented. There has recently been interest in milder forms of bipolar disorder in adolescents, such as bipolar II disorder (episodes of major depression and hypomania) and cyclothymia (chronic mild states characterized by symptoms such as irritability, decreased need for sleep, and so on).