This paper presents how numerical optimization methods, like topology optimization, and new design possibilities through additive manufacturing (AM) can be used for structural improvements of the load introduction points in sandwich structures. A new design approach is presented, which allows a direct load-path optimized integration of the load introduction point into the sandwich core. The corresponding methodical procedure is shown and the application is demonstrated exemplarily for a sandwich structure with a honeycomb core. The advantages for design science are that the new design possibilities of AM can be considered and used when designing the load introduction points. Thus, the additional reinforcements of the sandwich structures to absorb locally introduced forces in the lightweight structure can be minimized. This enables a meaningful technical comparison and it can be decided in the future whether such a design can be used for sandwich structures under economic aspects. In addition, the influence of the initial and boundary conditions on the design is presented and discussed in this paper. The challenges of optimizing multiple load introduction points simultaneously as well as the special aspects to be considered when transferring the design approach to larger sandwich structures are also highlighted.