We study monotone operators in reflexive Banach spaces that are invariant with respect to a group of suitable isometric isomorphisms, and we show that they always admit a maximal extension which preserves the same invariance. A similar result applies to Lipschitz maps in Hilbert spaces, thus providing an invariant version of Kirszbraun–Valentine extension theorem. We then provide a relevant application to the case of monotone operators in $L^{p}$-spaces of random variables which are invariant with respect to measure-preserving isomorphisms, proving that they always admit maximal dissipative extensions which are still invariant by measure-preserving isomorphisms. We also show that such operators are law invariant, a much stronger property which is also inherited by their resolvents, the Moreau–Yosida approximations, and the associated semigroup of contractions. These results combine explicit representation formulae for the maximal extension of a monotone operator based on self-dual Lagrangians and a refined study of measure-preserving maps in standard Borel spaces endowed with a nonatomic measure, with applications to the approximation of arbitrary couplings between measures by sequences of maps.