One of the most popular instruments used to assess perceived social support is the Multidimensional Scale of Perceived Social Support (MSPSS). Although the original structure of the MSPSS was defined to include three specific factors (significant others, friends and family), studies in the literature propose different factor solutions. In this study, we addressed the controversial factor structure of the MSPSS using a meta-analytic confirmatory factor analysis approach. For this purpose, we utilized studies in the literature that examined and reported the internal structure of the MSPSS. However, we used summary data from 59 samples of 54 studies (total N = 27,905) after excluding studies that did not meet the inclusion criteria. We tested five different models discussed in the literature and found that the fit indices of the correlated 3-factor model and the bifactor model were quite good. Therefore, we also examined both models’ factor loadings and omega coefficients. Since there was no sharp difference between the two models and the theoretical structure of the scale was represented by the correlated three factors, we decided that the correlated three-factor model was more appropriate for the internal structure of the MSPSS. We then examined the measurement invariance for this model according to language and sample type (clinical and nonclinical) and found that metric invariance was achieved. As a result, we found that the three-factor structure of the MSPSS was supported in this study.