A cancer diagnosis is likely to have a devastating effect when it occurs, but it is possibly especially problematic during adolescence. The many challenges faced by adolescents have led to a concern for their psychosocial well-being. There is evidence to support the notion that the provision of effective psychosocial care improves the outcomes of patients with cancer. The review of the literature has identified that amongst the psychological challenges; there is uncertainty and fear around the status and progression of the cancer. Issues such as body image and sexuality and fertility have been highlighted as a major cause of concern for adolescents. The literature suggests health professionals need to be trained in such areas to give the appropriate care and support. It has also been identified that hopefulness and a positive attitude by patients, families and the multi disciplinary team contribute to positive outcomes. Nurses play a key role in providing psychosocial care as they are primarily the ones who deliver the daily care and can be used as a mediator between the multi disciplinary team. Other disciplines such as Clinical Nurse Specialists, Activities Coordinators, Social workers and Psychotherapists all contribute to the overall direction and experience of care.