This paper investigates the flow boiling heat transfer in microchannels with the aim ofdeveloping compact cooling systems which can be adapted to miniaturized power components.Nano- and micro-surface treatments were used as innovative techniques to improve the heattransfer performance as well as to delay the intermittent dryout. It was observed that themicro-structured surfaces show significant enhancements (up to 85%) in heat transfercompared to the smooth surfaces. Especially, using the highly-wetted structured surface,the intermittent dryout is improved.