A model of tumor growth in a spatial environment is analyzed. The model includesproliferating and quiescent compartments of tumor cells indexed by successively mutated cell phenotypesof increasingly proliferative aggressiveness. The model incorporates spatial dependencedue to both random motility and directed movement haptotaxis. The model structures tumor cellsby both cell age and cell size. The model consists of a system of nonlinear partial differentialequations for the compartments of tumor cells, extracellular matrix, matrix degradative enzyme,and oxygen. The existence, uniqueness, positivity, regularity, and growth characteristics of thesolutions are investigated.

A hyperelastic constitutive law, for use in anatomically accurate finite element models ofliving structures, is suggested for the passive and the active mechanical properties of incompressiblebiological tissues. This law considers the passive and active states as a same hyperelastic continuummedium, and uses an activation function in order to describe the whole contraction phase.The variational and the FE formulations are also presented, and the FE code has been validatedand applied to describe the biomechanical behavior of a thick-walled anisotropic cylinder underdifferent active loading conditions.