Plotinus’ understanding of self is formulated largely in dialogue with the Stoics. In early works he categorically rejects the Stoic notion of the hēgemonikon (‘leading part’ or ‘commanding faculty’) of the soul. In this paper, I show how, in light of a general dissatisfaction with the Stoic account of self articulated in his early work, Plotinus deals with the Stoic notion of oikeiōsis (‘appropriation’). I argue that Plotinus’ understanding of oikeiōsis develops across the period during which he uses it. In his middle writings, Plotinus engages with Stoic oikeiōsis by exploring how it functions in contexts related to selfhood. In his later writings, he shows, on the one hand, how the concept of oikeiōsis can be Platonized, such as to account for the relation of the self to the Good, and, on the other, how the Stoic understanding of oikeiōsis is untenable for many of the same reasons that he rejects the Stoic notion of the hēgemonikon. Ultimately, Plotinus thinks that Stoic understandings of the hēgemonikon and oikeiōsis are untenable because they lead to something that could be characterized as ‘selfishness’.