In this article, we consider a twisted partial action $\unicode[STIX]{x1D6FC}$ of a group $G$ on an associative ring $R$ and its associated partial crossed product $R\ast _{\unicode[STIX]{x1D6FC}}^{w}G$. We provide necessary and sufficient conditions for the commutativity of $R\ast _{\unicode[STIX]{x1D6FC}}^{w}G$ when the twisted partial action $\unicode[STIX]{x1D6FC}$ is unital. Moreover, we study necessary and sufficient conditions for the simplicity of $R\ast _{\unicode[STIX]{x1D6FC}}^{w}G$ in the following cases: (i) $G$ is abelian; (ii) $R$ is maximal commutative in $R\ast _{\unicode[STIX]{x1D6FC}}^{w}G$; (iii) $C_{R\ast _{\unicode[STIX]{x1D6FC}}^{w}G}(Z(R))$ is simple; (iv) $G$ is hypercentral. When $R=C_{0}(X)$ is the algebra of continuous functions defined on a locally compact and Hausdorff space $X$, with complex values that vanish at infinity, and $C_{0}(X)\ast _{\unicode[STIX]{x1D6FC}}G$ is the associated partial skew group ring of a partial action $\unicode[STIX]{x1D6FC}$ of a topological group $G$ on $C_{0}(X)$, we study the simplicity of $C_{0}(X)\ast _{\unicode[STIX]{x1D6FC}}G$ by using topological properties of $X$ and the results about the simplicity of $R\ast _{\unicode[STIX]{x1D6FC}}^{w}G$.