Experiments were conducted at three locations in North Carolina in 1999 and 2000 to evaluate weed management systems in strip-tillage peanut. Diclosulam was evaluated with standard preemergence (PRE), early postemergence, and postemergence (POST) herbicide systems in a factorial treatment arrangement. Preemergence treatments that contained diclosulam controlled common lambsquarters, common ragweed, and eclipta by 100%. Diclosulam PRE controlled entireleaf morningglory by 88%, ivyleaf morningglory by ≥ 90%, pitted morningglory by ≥ 81%, and prickly sida by ≥ 94%. Yellow nutsedge control with diclosulam ranged from 65 to 100% depending on location, whereas POST systems containing imazapic controlled yellow nutsedge by at least 89%, regardless of PRE herbicides. Peanut yields and net returns were reflective of levels of weed management. Systems that included diclosulam PRE plus POST herbicides consistently provided high yields and net returns. Clethodim late POST was required for full-season control of annual grasses, including broadleaf signalgrass, goosegrass, large crabgrass, and Texas panicum.