A study was conducted in 1999 to evaluate weed control and imidazolinone-tolerant (IMI-tolerant) rice response to 140 g ai/ha imazethapyr at different application timings and to flood depths of 5, 10, and 20 cm at the Rice Research Station near Crowley, LA, and at the Northeast Research Station near St. Joseph, LA. Barnyardgrass control, rice injury, and rice yield were not influenced by flood depth; therefore, data were averaged over flood depths. Season-long barnyardgrass control was greater than 80% at both locations with imazethapyr applied preplant incorporated (PPI), early postemergence (EPOST), and mid-postemergence (MPOST). IMI-tolerant rice injury at 7 d after late postemergence (LPOST) treatment (DAT) was less than 5% for all imazethapyr treatments at Crowley and 1 to 8% for PPI, preemergence (PRE), delayed preemergence (DPRE), and EPOST timings at St. Joseph. However, IMI-tolerant rice injury was 5% or less at 42 DAT for all treatments at Crowley and St. Joseph. IMI-tolerant rice yield at Crowley was 2,780 to 3,000 kg/ha following applications of imazethapyr at PPI, PRE, DPRE, and EPOST, and these yields were higher than the yields of the MPOST and LPOST treatments. At St. Joseph, IMI-tolerant rice yields were equal for imazethapyr applied PPI, DPRE, and EPOST treatments compared with Crowley.