This article presents the design of an ultra-compact cavity-backed self-diplexing antenna with high isolation employing quarter-mode substrate integrated waveguide (QMSIW). The proposed antenna is constructed by using QMSIW, slot, and two 50Ω feed lines. Two eighth-mode cavity resonators are designed by inserting a slot on the top side of the rectangular substrate integrated waveguide to operate at 2.6 and 4.9 GHz for long-term evolution and public safety band applications, respectively. The proposed design allows to tune any frequency band independently by keeping other bands unaltered. The size of antenna is ultra-compact, due to the use of QMSIW cavity. The isolation between two ports is >35 dB. The antenna achieves 5.34 and 5.68 dBi peak gains at 2.6 and 4.9 GHz, respectively. The efficiency of the antenna is >85% at both frequency bands. The antenna provides more than 20.9 dB front-to-back-ratio and better than 21 dB separation between co-to-cross polarization levels. The designed antenna is validated through fabrication and measurement.