Determining the best strategy for allocating weed management resources across and between landscapes is challenging because of the uncertainties and large temporal and spatial scales involved. Ecological models of invasive plant spread and control provide a practical tool with which to evaluate alternative management strategies at landscape scales. We developed a spatially explicit model for the spread and control of spotted knapweed and leafy spurge across three Montana landscapes. The objective of the model was to determine the ecological and economic costs and benefits of alternative strategies across landscapes of varying size and stages of infestation. Our results indicate that (1) in the absence of management the area infested will continue to increase exponentially leading to a substantial cost in foregone grazing revenues; (2) even though the costs of management actions are substantial, there is a net economic benefit associated with a broad range of management strategies; (3) strategies a that prioritize targeting small new infestations consistently outperform strategies that target large established patches; and (4) inconsistent treatment and short-term delays can greatly reduce the economic and ecological benefits of management.