This paper proposes a novel design of a reconfigurable parallel kinematic manipulator used for a machine tool. After investigating the displacement and inverse kinematics of the proposed manipulator, it is found that the parasitic motions along x-, y-, and θz-axes can be eliminated. The system stiffness of the parallel manipulator is conducted. In order to locate the highest system stiffness, single and multiobjective optimizations are performed in terms of rotation angles in x- and y-axes and translation displacement in z-axis. Finally, a case study of tool path planning is presented to demonstrate the application of stiffness mapping. Through this integrated design synthesis process, the system stiffness optimization is conducted with Genetic Algorithms. By optimizing the design variables including end-effector size, base platform size, the distance between base platform and middle moving platform, and the length of the active links, the system stiffness of the proposed parallel kinematic manipulator has been greatly improved.