This study advances neorealist theory by examining how systemic constraints shape state behavior through economic statecraft, focusing on China’s Belt and Road Initiative (BRI) and Iran’s strategic calculations. Employing methodological triangulation – network analysis, discourse examination, and institutional assessment – this research explores the strategic logic underpinning the China-Iran engagement. For Iran, the BRI emerges as a mechanism for institutional resilience and sanctions circumvention, though its integration remains constrained by systemic limitations and regional competition. For China, the BRI serves as a geopolitical infrastructure strategy to expand influence and secure resources, despite concerns over economic sustainability. By framing economic statecraft as a strategic response to systemic constraints, this study challenges conventional materialist and militaristic paradigms of international relations. It critically assesses the generalizability of BRI partnerships, illustrating how states, bound by structural limitations, use economic instruments to reshape their strategic environments. Ultimately, the research offers nuanced insight into emerging power dynamics in a multipolar world, extending beyond traditional power-centric models.