The uncertainty and insecurity generated by COVID-19 has greatly reshaped work styles, bringing employees more strain and less engagement and subsequently making human resource management (HRM) more challenging. There has been a growing interest in employee work engagement in the field of HRM. This study utilized positive psychology and the job demands-resources model to explore the mediating mechanism between high-performance work systems (HPWS) and employee work engagement. Based on survey data from 71 senior HR managers and 288 employees of 71 China's manufacturing state-owned enterprises, multilevel structural equation modeling shows that HPWS is positively related to work engagement. Employee-perceived internal marketability fully mediates the relationship between HPWS and work engagement. The key result of this paper is that employee-perceived internal marketability is seen as a core personal psychological resource that can be developed through HPWS to benefit both employers and employees.