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Single catheter 3D volume-based hybrid inverse planning optimisation in IVBT can improve organ sparing

Published online by Cambridge University Press:  16 October 2023

Bijay Kumar Barik Open the ORCID record for Bijay Kumar Barik [Opens in a new window] ,
Juliepriya Jena ,
Dillip Kumar Sahoo ,
Anupam Kumar Muraleedharan ,
Santosh Kumar Parida ,
Bikash Ranjan Mohapatra ,
Sandip Kumar Barik ,
Deepak Kumar Das ,
Saroj Kumar Das Majumdar  and
Dillip Kumar Parida
Bijay Kumar Barik*
Affiliation:
Department of Radiation Oncology, All India Institute of Medical Sciences, Bhubaneswar, India
Juliepriya Jena
Affiliation:
Army Hospital Research and Referral, New Delhi, India
Dillip Kumar Sahoo
Affiliation:
Department of Radiation Oncology, All India Institute of Medical Sciences, Bhubaneswar, India
Anupam Kumar Muraleedharan
Affiliation:
Department of Radiation Oncology, All India Institute of Medical Sciences, Bhubaneswar, India
Santosh Kumar Parida
Affiliation:
Department of Physics, ITER, Siksha O Anusandhan Deemed to be University, Bhubaneswar, India
Bikash Ranjan Mohapatra
Affiliation:
Department of Radiation Oncology, All India Institute of Medical Sciences, Bhubaneswar, India
Sandip Kumar Barik
Affiliation:
Department of Radiation Oncology, All India Institute of Medical Sciences, Bhubaneswar, India
Deepak Kumar Das
Affiliation:
Department of Radiation Oncology, All India Institute of Medical Sciences, Bhubaneswar, India
Saroj Kumar Das Majumdar
Affiliation:
Department of Radiation Oncology, All India Institute of Medical Sciences, Bhubaneswar, India
Dillip Kumar Parida
Affiliation:
Department of Radiation Oncology, All India Institute of Medical Sciences, Bhubaneswar, India
*
Corresponding author: Bijay Kumar Barik; Email: bijaybarik007@gmail.com
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Abstract

Purpose:

To analyse the dosimetric benefit of the hybrid inverse planning optimisation (HIPO) planning method over the graphical optimisation (GrO) planning method for 3D volume-based intravaginal brachytherapy (IVBT) in a mono-centre patient cohort.

Material and methods:

Twenty-five patients surgically staged with endometrial cancer were considered for the study. All the patients had received adjuvant IVBT for three fractions with one-time computed tomography image-based planning. The data on the patient, tumour, plan, and treatment characteristics were retrieved from the database. All the plans were re-optimised with GrO and HIPO techniques for this comparison study. The different dosimetric parameters were compared between the two methods, and the collected data were tabulated and shown graphically. The statistical evaluation was performed with IBM SPSS version 26, and Origin Pro 8.5 was employed for plots.

Results:

HIPO plans show similar target coverage in terms of D 90(%), V 95(%) and conformity index with no significant statistical difference from the GrO plans with an acceptable increase in homogeneity index (0·087 ± 0·062%). It succeeds in achieving a statistically significant reduction of dose to organs at risk such as D0·1 cc, D1·0 cc and D2·0 cc for the bladder (11·59%, 4·8% and 3·99%), rectum (41·33%, 16·9% and 16·05%) and sigmoid (20·97%, 13·53% and 11·21%), respectively, in comparison with GrO optimisation.

Conclusion:

Considering the dosimetric outcome of 3D-based IVBT, it is suggested to adopt inverse optimisation techniques like HIPO over GrO to achieve higher quality treatment plan in terms of adequate target dose and lesser dose to OARs.

Keywords

DVH – dose volume histogramgraphical optimisationhybrid inverse planning optimisationintravaginal brachytherapyorgans at risk
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 22 , 2023 , e111
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Copyright
© The Author(s), 2023. Published by Cambridge University Press

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Footnotes

Article last updated 13 November 2023

*

This article has been updated since original publication. A notice detailing the change has also been published

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