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Chapter 12 - Cutaneous Infections

Published online by Cambridge University Press:  17 June 2025

By
Wun Ju Shieh  and
Mai P. Hoang
Edited by
Mai P. Hoang
Mai P. Hoang
Affiliation:
Harvard Medical School, Boston
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Summary

Skin infections can be caused by bacteria, viruses, parasites, and fungi. While some of the infections are self-limited, others can spread beyond the skin and become systemic resulting in fatal outcome when without appropriate treatment. A crucial step toward making the etiologic diagnosis of infection is sample collection with pertinent laboratory testing. In conjunction with culture, serology, special stains, immunohistochemistry, electron microscopy, and molecular assays, a skin biopsy can provide useful diagnostic information together with clinicopathologic correlation. Using antibodies either commercially available or only at highly specialized laboratories such as the Centers for Disease Control and Prevention, immunohistochemistry can detect the presence of microbial antigens in skin biopsies. Immunohistochemistry can play an important role in determining an infectious etiology. It is useful in detecting fastidious or slow-growing organisms, is valuable for characterizing emerging infections or pathogens with high biosafety concern and provides immunolocalization of antigens facilitating correlation between the infectious pathogen and host tissue response.

Keywords

infectionbacteriavirusparasitefungus
Type
Chapter
Information
Immunohistochemistry and Ancillary Studies in Diagnostic Dermatopathology , pp. 380 - 419
Publisher: Cambridge University Press
Print publication year: 2025

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