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Chapter 6 - Cutaneous Lymphoid Neoplasms

Published online by Cambridge University Press:  17 June 2025

By
Mai P. Hoang  and
M. Angelica Selim
Edited by
Mai P. Hoang
Mai P. Hoang
Affiliation:
Harvard Medical School, Boston
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Summary

Primary cutaneous lymphomas comprise a group of B- and T-cell lymphomas that do not have extracutaneous involvement at the time of diagnosis. They are the second most common group of extranodal lymphomas. Cutaneous B-cell lymphomas are generally classified into three main subgroups: cutaneous marginal zone B-cell lymphoma, cutaneous follicle center lymphoma, and cutaneous large B-cell lymphoma, leg type. Cutaneous T-cell and NK-cell lymphomas can derive from the helper T-cells (CD4+), cytotoxic T-cells (CD8+), gamma-delta T-cells (CD56+), or follicle helper T-cells (CD279/PD1). Immunohistochemistry plays an important role in the classification of B- and T-cell lymphoid lesions. A number of immunostains have recently become commercially available and can serve as diagnostic adjuncts in cases lacking characteristic immunohistochemical staining.

Keywords

LymphomaB-cellT-cellNK-cellanaplasticplasmacytoid dendritic cellplasmablastic
Type
Chapter
Information
Immunohistochemistry and Ancillary Studies in Diagnostic Dermatopathology , pp. 145 - 197
Publisher: Cambridge University Press
Print publication year: 2025

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