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Chapter 5 - Inflammatory Dermatoses Mimicking Lymphomas

Published online by Cambridge University Press:  17 June 2025

By
Emily M. Hartsough ,
M. Angelica Selim  and
Mai P. Hoang
Edited by
Mai P. Hoang
Mai P. Hoang
Affiliation:
Harvard Medical School, Boston
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Summary

Pseudolymphomas can be comprised of a prominent infiltrate of B cells, T cells, and even plasma cells. In these settings, they can mimic a lymphoproliferative process and immunohistochemistry plays an important role in excluding cutaneous lymphoma. B-cell pseudolymphomas or cutaneous lymphoid hyperplasia can mimic cutaneous follicle center cell lymphoma and primary cutaneous marginal zone B-cell lymphoma histopathologically. T-cell pseudolymphomas include a variety of inflammatory dermatoses that exhibit epidermotropism and can mimic a T-cell lymphoproliferative disorders such as mycosis fungoides. Some examples include lymphomatoid contact dermatitis, lymphomatoid drug eruption, follicular mucinosis, lupus erythematosus panniculitis, pigmented purpuric dermatosis, pityriasis lichenoides chronica/pityriasis lichenoides et varioliformis acuta, and pseudolymphomatous folliculitis. In some instances, the infiltrate is rich in plasma cells as in IgG4-related disease in the skin. Ultimately clinical pathologic correlation and sometimes the use of molecular studies will allow the classification of these entities.

Keywords

Cutaneous lymphoid hyperplasiafollicular mucinosislupus panniculitispseudolymphomatous folliculitis
Type
Chapter
Information
Immunohistochemistry and Ancillary Studies in Diagnostic Dermatopathology , pp. 112 - 144
Publisher: Cambridge University Press
Print publication year: 2025

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