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Chapter 9 - Miscellaneous Tumors

Published online by Cambridge University Press:  17 June 2025

By
Soma Jobbagy  and
Mai P. Hoang
Edited by
Mai P. Hoang
Mai P. Hoang
Affiliation:
Harvard Medical School, Boston
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Summary

The histogenesis of a variety of tumors such as epithelioid sarcoma, alveolar soft part sarcoma, and synovial sarcoma remains unknown. Tumors of histiocytic origin include Erdheim-Chester disease and histiocytic sarcoma and dendritic cell tumors include Langerhans cell histiocytosis, follicular dendritic cell sarcoma, and interdigitating dendritic cell sarcoma. Despite their similar histopathologic appearance, tumors of histiocytic and dendritic cell origin have different immunoprofile and immunohistochemistry is essential in classifying these tumors. Leukemia cutis or granulocytic or myeloid sarcoma is comprised of immature myeloid precursor cells. Lymphoblastic lymphomas are derived from precursor B- or T-cell lymphocytes. Cutaneous involvement can be the sole manifestation of these diseases, during or after development of bone marrow leukemia. In this chapter these miscellaneous entities as well as Merkel cell carcinoma, myoepithelioma, myoepithelial carcinoma, Ewing sarcoma, and mast cell infiltrate are discussed.

Keywords

Merkel cell carcinomahistiocytic neoplasmsmast cell diseaseleukemic infiltrate
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Immunohistochemistry and Ancillary Studies in Diagnostic Dermatopathology , pp. 297 - 332
Publisher: Cambridge University Press
Print publication year: 2025

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