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Chapter 8 - Soft Tissue Neoplasms

Published online by Cambridge University Press:  17 June 2025

By
Jakob M. T. Moran ,
Joana Pardal  and
Mai P. Hoang
Edited by
Mai P. Hoang
Mai P. Hoang
Affiliation:
Harvard Medical School, Boston
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Summary

Pathologists often encounter soft tissue neoplasms while examining biopsies and excisions from the skin. Soft tissue neoplasms are classified along their line of differentiation and include fibroblastic, myofibroblastic and fibrohistiocytic tumors, smooth muscle tumors, skeletal muscle tumors, neural tumors, lipomatous tumors, vascular tumors, pericytic and perivascular tumors and tumors of uncertain differentiation. These tumors can be categorized as benign, intermediate (locally recurrent/aggressive), intermediate (rarely metastasizing) and malignant (locally recurrent/aggressive with significant metastatic potential). Histologic diagnosis, grading and staging is imperative for prognostication and treatment. The continually expanding array of molecular diagnostics techniques has identified numerous novel gene alterations in soft tissue neoplasms that has enabled identification of new diagnostic entities with accompanying diagnostic and surrogate immunohistochemical markers. In this chapter we will review many soft tissue neoplasms and highlight important immunohistochemical markers.

Keywords

Soft tissuefibrohistiocyticmyogenicmyofibroblasticneurallipomatousvascular
Type
Chapter
Information
Immunohistochemistry and Ancillary Studies in Diagnostic Dermatopathology , pp. 235 - 296
Publisher: Cambridge University Press
Print publication year: 2025

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