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Section 9 - Fungal Infections

Published online by Cambridge University Press:  18 June 2025

David Mabey
Affiliation:
London School of Hygiene and Tropical Medicine
Martin W. Weber
Affiliation:
World Health Organization
Moffat Nyirenda
Affiliation:
London School of Hygiene and Tropical Medicine
Dorothy Yeboah-Manu
Affiliation:
Noguchi Memorial Institute for Medical Research, University of Ghana
Jackson Orem
Affiliation:
Uganda Cancer Institute, Kampala
Laura Benjamin
Affiliation:
University College London
Michael Marks
Affiliation:
London School of Hygiene and Tropical Medicine
Nicholas A. Feasey
Affiliation:
Liverpool School of Tropical Medicine
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Publisher: Cambridge University Press
Print publication year: 2025

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References

Armstrong-James, D., Meintjes, G. & Brown, G. D. (2014) A neglected epidemic: fungal infections in HIV/AIDS. Trends Microbiol, 22(3), 120–7.10.1016/j.tim.2014.01.001CrossRefGoogle ScholarPubMed
Bongomin, F., Gago, S., Oladele, R. O. & Denning, D. W. (2017) Global and multi-national prevalence of fungal diseases-estimate precision. J Fungi (Basel), 3(4).Google ScholarPubMed
Boulware, D. R., Meya, D. B., Muzoora, C. et al. (2014) Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. N Engl J Med, 370(26), 2487–98.10.1056/NEJMoa1312884CrossRefGoogle ScholarPubMed
Hay, R., Denning, D. W., Bonifaz, A., Queiroz-Telles, F. et al. (2019) The diagnosis of fungal neglected tropical diseases (fungal NTDs) and the role of investigation and laboratory tests: an expert consensus report. Trop Med Infect Dis, 4(4).10.3390/tropicalmed4010004CrossRefGoogle ScholarPubMed
Kontoyiannis, D. P., Wessel, V. C., Bodey, G. P. & Rolston, K. V. (2000) Zygomycosis in the 1990s in a tertiary-care cancer center. Clin Infect Dis, 30(6), 851–6.10.1086/313803CrossRefGoogle Scholar
Lawrence, D. S., Youssouf, N., Molloy, S. F. et al. (2018) AMBisome Therapy Induction OptimisatioN (AMBITION): High dose AmBisome for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a phase 3 randomised controlled non-inferiority trial. Trials, 19(1), 649.10.1186/s13063-018-3026-4CrossRefGoogle ScholarPubMed
Loyse, A., Dromer, F., Day, J., Lortholary, O. & Harrison, T. S. (2013) Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. J Antimicrob Chemother, 68(11), 2435–44.10.1093/jac/dkt221CrossRefGoogle ScholarPubMed
May, R. C., Stone, N. R., Wiesner, D. L., Bicanic, T. & Nielsen, K. (2016) Cryptococcus: from environmental saprophyte to global pathogen. Nat Rev Microbiol, 14(2), 106–17.10.1038/nrmicro.2015.6CrossRefGoogle ScholarPubMed
McBride, J. A., Gauthier, G. M. & Klein, B. S. (2017) Clinical manifestations and treatment of blastomycosis. Clin Chest Med, 38(3), 435–49.10.1016/j.ccm.2017.04.006CrossRefGoogle ScholarPubMed
Muzoora, C. K., Kabanda, T., Ortu, G. et al. (2012) Short course amphotericin B with high dose fluconazole for HIV-associated cryptococcal meningitis. J Infect, 64(1), 7681.10.1016/j.jinf.2011.10.014CrossRefGoogle ScholarPubMed
Oladele, R. O., Ayanlowo, O. O., Richardson, M. D. & Denning, D. W. (2018) Histoplasmosis in Africa: an emerging or a neglected disease? PLoS Negl Trop Dis, 12(1), e0006046.10.1371/journal.pntd.0006046CrossRefGoogle ScholarPubMed
Oladele, R. O., Ly, F., Sow, D., Akinkugbe, A. O., Ocansey, B. K., Fahal, A. H. & van de Sande, W. W. J. (2021) Mycetoma in West Africa. Trans R Soc Trop Med Hyg, 115(4), 328–36.10.1093/trstmh/trab032CrossRefGoogle Scholar
Prakash, H. & Chakrabarti, A. (2019) Global epidemiology of mucormycosis. J Fungi (Basel), 5(1).Google ScholarPubMed
Queiroz-Telles, F. (2015) Chromoblastomycosis: a neglected tropical disease. Rev Inst Med Trop Sao Paulo, 57 Suppl. 19, 4650.10.1590/S0036-46652015000700009CrossRefGoogle ScholarPubMed
Rajasingham, R., Smith, R. M., Park, B. J. et al. (2017) Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect Dis, 17(8), 873–81.10.1016/S1473-3099(17)30243-8CrossRefGoogle ScholarPubMed
Ribes, J. A., Vanover-Sams, C. L. & Baker, D. J. (2000) Zygomycetes in human disease. Clin Microbiol Rev, 13(2), 236301.10.1128/CMR.13.2.236CrossRefGoogle ScholarPubMed
Roden, M. M., Zaoutis, T. E., Buchanan, W. L. et al. (2005) Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis, 41(5), 634–53.10.1086/432579CrossRefGoogle ScholarPubMed
Sarkar, S., Gokhale, T., Choudhury, S. S. & Deb, A. K. (2021) COVID-19 and orbital mucormycosis. Indian J Ophthalmol, 69(4), 1002–4.10.4103/ijo.IJO_3763_20CrossRefGoogle ScholarPubMed
Schwartz, I. S., Muñoz, J. F., Kenyon, C. R. et al. (2020) Blastomycosis in Africa and the Middle East: a comprehensive review of reported cases and reanalysis of historical isolates based on molecular data. Clin Infect Dis. doi: 10.1093/cid/ciaa1100.CrossRefGoogle Scholar
van de Sande, W. W. (2013) Global burden of human mycetoma: a systematic review and meta-analysis. PLoS Negl Trop Dis, 7(11), e2550.10.1371/journal.pntd.0002550CrossRefGoogle ScholarPubMed
van der Horst, C. M., Saag, M. S., Cloud, G. A. et al. (1997) Treatment of cryptococcal meningitis associated with the acquired immunodeficiency syndrome. National Institute of Allergy and Infectious Diseases Mycoses Study Group and AIDS Clinical Trials Group. N Engl J Med, 337(1), 1521.CrossRefGoogle Scholar
Wake, R. M., Britz, E., Sriruttan, C. et al. (2018) High cryptococcal antigen titers in blood are predictive of subclinical cryptococcal meningitis among human immunodeficiency virus-infected patients. Clin Infect Dis, 66(5), 686–92.10.1093/cid/cix872CrossRefGoogle ScholarPubMed
Warnock, D. W. & Richardson, M. D. (2012) Fungal Infection: Diagnosis and Management. 4th ed. Chichester: Wiley–Blackwell.Google Scholar
WHO (2018) Guidelines for the diagnosis, prevention, and management of cryptococcal disease in HIV-infected adults, adolescents and children, March 2018: supplement to the 2016 consolidated guidelines of the use of antiretroviral drugs for treating and preventing HIV infection.Google Scholar

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