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Chapter 13 - Measles

from Section 2 - Mother and Child Health

Published online by Cambridge University Press:  18 June 2025

David Mabey
Affiliation:
London School of Hygiene and Tropical Medicine
Martin W. Weber
Affiliation:
World Health Organization
Moffat Nyirenda
Affiliation:
London School of Hygiene and Tropical Medicine
Dorothy Yeboah-Manu
Affiliation:
Noguchi Memorial Institute for Medical Research, University of Ghana
Jackson Orem
Affiliation:
Uganda Cancer Institute, Kampala
Laura Benjamin
Affiliation:
University College London
Michael Marks
Affiliation:
London School of Hygiene and Tropical Medicine
Nicholas A. Feasey
Affiliation:
Liverpool School of Tropical Medicine
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Summary

The global measles problem is worst in sub-Saharan Africa where the incidence and mortality are highest, and vaccine coverage is lowest. Reported measles cases fell from 520,102 in 2000 to 36,269 in 2016, but there was a steep increase in cases to 618,595 in 2019 (Patel et al. 2020). In 2019–2020, the world’s largest single-nation measles outbreak occurred in the Democratic Republic of the Congo with more than 6,000 deaths and 310,000 suspected cases. The recent increase in the incidence of and mortality from measles in Africa is connected to concurrent disease outbreaks and recurrent conflicts that have disrupted many vaccination programmes.

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Publisher: Cambridge University Press
Print publication year: 2025

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References

Aaby, P & Clements, CJ (1989). Measles immunization research: a review. Bull Wld Hlth Org; 67: 443–8.Google ScholarPubMed
Aaby, P (1998). Malnutrition and overcrowding – exposure in severe measles infection; a review of community studies. Rev Infect Dis; 10: 478–91.Google Scholar
Akramuzzaman, SM et al. (2000). Increased childhood morbidity after measles is short-term in urban Bangladesh. J Epidemiol; 151: 723–35.Google ScholarPubMed
Barrett, T (1999). Morbillivirus infections, with special emphasis on morbillivirus of carnivores. Vet Microbiol; 69: 313.CrossRefGoogle ScholarPubMed
Benn, CS et al (2020). Vaccinology: time to change the paradigm? Lancet Inf Dis; 10: e274e283.CrossRefGoogle Scholar
Burnet, FM (1968). Measles as an index of immunological function. Lancet; ii: 610–13.Google Scholar
Do, LAH et al. (2020). Exploring the possible cause of the dramatic increase in measles mortality during the 2015–2016 Mongolian outbreak. J Infect Dis; 7(1): 1266–8.Google Scholar
Griffin DE, Ward BJ & Esolen LM (1994). Pathogenesis of measles virus infection: an hypothesis for the altered immune responses. J Infect Dis; 170: s24–s31.Google Scholar
Guerra, FM et al. (2017). The basic reproduction number (R0) of measles: a systematic review. Lancet Infect Dis; 17(12): e420e428.CrossRefGoogle ScholarPubMed
Hussey, GD, Klein, M (1990). A randomised, controlled trial of vitamin A in children with severe measles. N Engl J Med; 323: 160–4.CrossRefGoogle ScholarPubMed
Mina, MJ et al. (2015) Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality. Science; 348: 694–9.10.1126/science.aaa3662CrossRefGoogle ScholarPubMed
Moss, WJ et al. (2002). Prospective study of measles in hospitalized, HIV-infected and uninfected children in Zambia. Clin Infect Dis; 35: 189–96.CrossRefGoogle ScholarPubMed
Mulholland, K et al. (2020). Action needed now to prevent further increases in measles and measles deaths in the coming years. Lancet; 396: 1782–4.CrossRefGoogle ScholarPubMed
Patel, MK et al. (2020). Progress towards regional measles elimination – worldwide, 2000 – 2019. MMWR Morb Mortal Wkly Rep; 69(45): 17005.10.15585/mmwr.mm6945a6CrossRefGoogle Scholar
Permar, SR et al. (2001). Prolonged measles virus shedding in human immunodeficiency virus – infected children, detected by reverse transcriptase – polymerase chain reaction. J Infect Dis; 183: 532–8.10.1086/318533CrossRefGoogle Scholar
Petrova, VN et al. (2019). Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles. Sci Immunol; 4.CrossRefGoogle ScholarPubMed
Plotkin, S et al. (2012). Passive immunisation. In Plotkin, S., Orenstein, W., Offit, P., eds. Vaccines. 6th ed. Saunders; 807.Google Scholar
Portnoy, A et al. (2019). Estimates of case-fatality ratios of measles in low-income and middle-income countries: a systematic review and modelling analysis. Lancet Glob Health; 7(4): e472e481.CrossRefGoogle ScholarPubMed
Rota, P et al. (2016). Measles. Nat Rev Dis Primers; 2, 16049.CrossRefGoogle ScholarPubMed
Salama, P et al. (2001). Malnutrition, mortality, and humanitarian response during a famine in Ethiopia, JAMA; 286(5): 563–71.CrossRefGoogle Scholar
Scott, S et al. (2007). The influence of HIV-1 exposure and infection on levels of passively acquired antibodies to measles virus in Zambian infants. Clin Infect Dis; 45: 1417–24.CrossRefGoogle ScholarPubMed
Smythe, PM et al. (1971). Thymolymphatic deficiency and depression of cell-mediated immunity in protein calorie malnutrition. Lancet; ii: 939–43.Google Scholar
Wariri, O et al. (2021). A scorecard of progress towards measles elimination in 15 west African countries, 2001–19: a retrospective, multicountry analysis of national immunisation coverage and surveillance data. Lancet Glob Health; 9: e280–90.10.1016/S2214-109X(20)30481-2CrossRefGoogle ScholarPubMed
Whittle, HC et al. (1979). Severe ulcerative herpes of mouth and eye following measles. Trans Roy Soc Trop Med Hyg; 73: 66–9.10.1016/0035-9203(79)90132-9CrossRefGoogle ScholarPubMed
Wolfson, LJ et al. (2009). Estimates of measles case fatality ratios: a comprehensive review of community-based studies. Int J Epidemiol; 38(1): 192205.10.1093/ije/dyn224CrossRefGoogle ScholarPubMed
WHO (2013). Pocket Book of Hospital Care for Children: Guidelines for the Management of Common Childhood Illnesses.Google Scholar
WHO (2019). Recommendation for routine immunization.Google Scholar
WHO (2020). Guide for clinical case management and infection prevention and control during a measles outbreak. Geneva. Licence: CC BY-NC-SA 3.0 IGO.Google Scholar

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