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Chapter 14 - Pertussis

from Section 2 - Mother and Child Health

Published online by Cambridge University Press:  18 June 2025

David Mabey
Affiliation:
London School of Hygiene and Tropical Medicine
Martin W. Weber
Affiliation:
World Health Organization
Moffat Nyirenda
Affiliation:
London School of Hygiene and Tropical Medicine
Dorothy Yeboah-Manu
Affiliation:
Noguchi Memorial Institute for Medical Research, University of Ghana
Jackson Orem
Affiliation:
Uganda Cancer Institute, Kampala
Laura Benjamin
Affiliation:
University College London
Michael Marks
Affiliation:
London School of Hygiene and Tropical Medicine
Nicholas A. Feasey
Affiliation:
Liverpool School of Tropical Medicine
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Summary

Pertussis, also known as whooping cough, is a highly infectious acute respiratory disease that typically affects children. The causative organism is mainly Bordetella pertussis with a minority of cases caused by Bordetella parapertussis. The World Health Organization estimated that 24.1 million cases of pertussis occurred worldwide in 2014, resulting in an estimated 160,700 deaths in children under 5 years of age, with 58% of these occurring in the Africa region (Yeung et al. 2017). Pertussis can affect all age groups but presents as a more severe disease with a higher mortality in infancy and early childhood.

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Publisher: Cambridge University Press
Print publication year: 2025

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References

Aaby, P. (1992). Overcrowding and intensive exposure. Major determinants of variation in measles mortality in Africa. In Mortality and Society in Sub-Saharan Africa. Oxford: Clarendon Press, 319–48.Google Scholar
Altunaiji, S., Kukuruzovic, R., Curtis, N. & Massie, J. 2007. Antibiotics for whooping cough (pertussis). Cochrane Database Syst Rev, Cd004404.Google Scholar
Carbonetti, N. H. 2016. Pertussis leukocytosis: mechanisms, clinical relevance and treatment. Pathog Dis, 74.10.1093/femspd/ftw087CrossRefGoogle ScholarPubMed
Cherry, J. D., Tan, T., Wirsing Von Konig, C. H. et al. 2012. Clinical definitions of pertussis: Summary of a Global Pertussis Initiative roundtable meeting, February 2011. Clin Infect Dis, 54, 1756–64.CrossRefGoogle ScholarPubMed
Cody, C. L., Baraff, L. J., Cherry, J. D., Marcy, S. M. & Manclark, C. R. 1981. Nature and rates of adverse reactions associated with DTP and DT immunizations in infants and children. Pediatrics, 68, 650–60.CrossRefGoogle ScholarPubMed
Fulton, T. R., Phadke, V. K., Orenstein, W. A., Hinman, A. R., Johnson, W. D. & Omer, S. B. 2016. Protective effect of contemporary pertussis vaccines: a systematic review and meta-analysis. Clin Infect Dis, 62, 1100–10.10.1093/cid/ciw051CrossRefGoogle ScholarPubMed
Heininger, U., Weibel, D. & Richard, J. L. 2014. Prospective nationwide surveillance of hospitalizations due to pertussis in children, 2006–2010. Pediatr Infect Dis J, 33, 147–51.CrossRefGoogle ScholarPubMed
Jardine, A., Conaty, S. J., Lowbridge, C., Staff, M. & Vally, H. 2010. Who gives pertussis to infants? Source of infection for laboratory confirmed cases less than 12 months of age during an epidemic, Sydney, 2009. Commun Dis Intell Q Rep, 34, 116–21.Google ScholarPubMed
Macina, D. & Evans, K. E. 2021. Bordetella pertussis in school-age children, adolescents, and adults: a systematic review of epidemiology, burden, and mortality in Africa. Infect Dis Ther, 10, 1097–113.Google ScholarPubMed
Madsen, T. 1925. Whooping cough: its bacteriology, diagnosis, prevention and treatment. Boston Med Surg J, 192m 5060.CrossRefGoogle Scholar
Mulholland, K. 1995. Measles and pertussis in developing countries with good vaccine coverage. Lancet, 345, 305–7.10.1016/S0140-6736(95)90282-1CrossRefGoogle ScholarPubMed
Muloiwa, R., Wolter, N., Mupere, E. et al. 2018. Pertussis in Africa: findings and recommendations of the Global Pertussis Initiative (GPI). Vaccine, 36: 2385–93.CrossRefGoogle ScholarPubMed
Muloiwa, R., Dube, F. S., Nicol, M. P., Hussey, G. D. & Zar, H. J. 2020a. Risk factors for Bordetella pertussis disease in hospitalized children. PLoS ONE, 15, e0240717.CrossRefGoogle ScholarPubMed
Muloiwa, R., Kagina, B. M., Engel, M. E. & Hussey, G. D. 2020b. The burden of laboratory-confirmed pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunisation (EPI) in 1974: a systematic review and meta-analysis. BMC Med, 18, 233.10.1186/s12916-020-01699-3CrossRefGoogle ScholarPubMed
Patterson, J., Kagina, B. M., Gold, M., Hussey, G. D. & Muloiwa, R. 2018. Comparison of adverse events following immunisation with acellular and whole-cell pertussis vaccines: a systematic review. Vaccine, 36, 600716.10.1016/j.vaccine.2018.08.022CrossRefGoogle ScholarPubMed
Pierce, C., Klein, N. & Peters, M. 2000. Is leukocytosis a predictor of mortality in severe pertussis infection? Intensive Care Med, 26, 1512–14.CrossRefGoogle ScholarPubMed
Pollard, R. 1980. Relation between vaccination and notification rates for whooping cough in England and Wales. Lancet, 1, 1180–2.Google ScholarPubMed
Tatti, K. M., Sparks, K. N., Boney, K. O. & Tondella, M. L. 2011. Novel multitarget real-time PCR assay for rapid detection of Bordetella species in clinical specimens. J Clin Microbiol, 49, 4059–66.10.1128/JCM.00601-11CrossRefGoogle ScholarPubMed
Wendelboe, A. M., Van Rie, A., Salmaso, S. & Englund, J. A. 2005. Duration of immunity against pertussis after natural infection or vaccination. Pediatr Infect Dis J, 24, S5861.CrossRefGoogle ScholarPubMed
World Health Organization 2015. Pertussis vaccines: WHO position paper – August 2015. 35, 43360.Google Scholar
World Health Organization 2020. Progress and Challenges with Achieving Universal Immunization Coverage. WHO/UNICEF Estimates of National Immunization Coverage.Google Scholar
Yeung, K. H. T., Duclos, P., Nelson, E. a. S. & Hutubessy, R. C. W. 2017. An update of the global burden of pertussis in children younger than 5 years: a modelling study. Lancet Infect Dis, 17, 97480.10.1016/S1473-3099(17)30390-0CrossRefGoogle Scholar
Zerbo, O., Bartlett, J., Goddard, K., Fireman, B., Lewis, E. & Klein, N. P. 2019. Acellular pertussis vaccine effectiveness over time. Pediatrics, 144.10.1542/peds.2018-3466CrossRefGoogle ScholarPubMed

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