This article interrogates the concept of ‘polycrisis’ through a decolonial, Global South-centered lens, arguing that current polycrisis discourse inadequately addresses entrenched global inequalities and power asymmetries. It contends that the convergence of crises – ecological, economic, social, and political – is not a novel universal condition but a structural feature of neoliberal global capitalism, long experienced in the Global South. The paper conceptualizes the polycrisis as an organic crisis of hegemonic neoliberalism and imperial modernity. It foregrounds Global South epistemologies and counter-hegemonic responses to demonstrate how subaltern actors are theorizing and contesting global crises. Methodologically, it adopts an interdisciplinary, interpretive approach that privileges Southern knowledge production. The paper finally advocates for a post-neoliberal approach that center around equality, sustianability and justice to navigate the polycrisis.