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Chapter 17 - Deconstructing Hashimoto Encephalopathy

from Section 3 - Specific Syndromes and Diseases

Published online by Cambridge University Press:  27 January 2022

Josep Dalmau  and
Francesc Graus
Josep Dalmau
Affiliation:
Universitat de Barcelona
Francesc Graus
Affiliation:
Universitat de Barcelona
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Summary

This chapter critically reviews the diagnostic criteria of Hashimoto encephalopathy (HE) and the misuse of this diagnosis. HE is usually considered in patients with subacute cognitive deterioration, myoclonus, change in behaviour, or seizures, accompanied by normal or non-specific MRI and CSF findings, normal thyroid function or mild hypothyroidism, increased serum levels of thyroid peroxidase (TPO) antibodies, and clinical response to steroids. The beneficial effect of steroids was emphasized by renaming the disease ‘steroid-responsive encephalopathy associated with autoimmune thyroiditis’ (SREAT). However, the diagnosis of HE has several important limitations. One is that there are no specific biomarkers of the disease. Moreover, the specificity of TPO antibodies is poor as they are also found in 13% of healthy persons. The significance of antibodies against the amino (NH2)-terminal domain of α-enolase, considered a potential biomarker of HE, is also unclear. Another limitation is that the diagnostic confirmation of HE depends on steroid-responsiveness. However, the clinical criteria and paraclinical findings do not identify the patients that will respond to steroids (<30%). Finally, most patients reported with HE are not investigated for neuronal surface antibodies. Overall, the weaknesses of the criteria and their misuse characterizing as HE any neurological syndrome with positive TPO antibodies that responds to steroids, raise doubts about the clinical usefulness of the term HE.

Keywords

Hashimoto encephalopathyalpha enolase antibodiesautoimmune encephalitissteroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT)
Type
Chapter
Information
Autoimmune Encephalitis and Related Disorders of the Nervous System , pp. 460 - 475
Publisher: Cambridge University Press
Print publication year: 2022

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