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31 - Blood Biomarkers of Cognitive Health and Neurodegenerative Disease

from Part IV - Cognitive, Social, and Biological Factors across the Lifespan

Published online by Cambridge University Press:  28 May 2020

By
Mark Mapstone ,
Thomas J. Gross ,
Sudhakar Raja Subramaniam ,
Massimo S. Fiandaca  and
Howard J. Federoff
Edited by
Ayanna K. Thomas  and
Angela Gutchess
Ayanna K. Thomas
Affiliation:
Tufts University, Massachusetts
Angela Gutchess
Affiliation:
Brandeis University, Massachusetts
Get access

Summary

The aging of any biological system results in quantifiable change which may affect the output of the system in subtle or substantial ways. Human cognitive aging is no exception and the manner in which the system, in this case the brain, is able to withstand and/or adapt to the effects of age-related physiological change will determine the individual cognitive trajectory. In this chapter, we review the emerging field of blood biomarkers of cognitive aging with a focus on specific metabolic pathways implicated in cognitive health including cellular energetics, lipid metabolism, the maintenance of redox state, and inflammation. Challenges to blood biomarker development, including methodological and inferential limitations, are also reviewed. Ultimately, blood biomarkers of age-related neurodegenerative disease and cognitive success will provide clues for how we might all age successfully, reducing health care burden on societies and improving quality of life for individuals.

Keywords

cellular energeticsmetabolic pathwayscognitive healthlipid metabolismSupernormalinflammation
Type
Chapter
Information
The Cambridge Handbook of Cognitive Aging
A Life Course Perspective
 , pp. 568 - 586
Publisher: Cambridge University Press
Print publication year: 2020

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