Skip to main content Accessibility help
×
Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-27T12:59:08.621Z Has data issue: false hasContentIssue false

5 - Development During Infancy in Children Later Diagnosed with Autism Spectrum Disorder

from Part I - Foundations

Published online by Cambridge University Press:  26 September 2020

Jeffrey J. Lockman
Affiliation:
Tulane University, Louisiana
Catherine S. Tamis-LeMonda
Affiliation:
New York University
Get access

Summary

Autism spectrum disorder (ASD) is a heritable, heterogeneous, and common neurodevelopmental condition defined by impairments in social communication alongside restricted and repetitive behaviors (RRB). ASD is a moving target; its definition has changed dramatically over the years. The first comprehensive clinical descriptions of the condition were given by Leo Kanner and Hans Asperger more than 70 years ago (Asperger, 1944; Kanner, 1943), but it was not before 1980, with the publication of the third edition of the Diagnostic and Statistical Manual (DSM) of the American Psychiatric Association that the term autism was introduced as a formal category. At that time, only one criterion related to social interaction was listed (pervasive lack of responsiveness to other people).

Type
Chapter
Information
The Cambridge Handbook of Infant Development
Brain, Behavior, and Cultural Context
, pp. 128 - 154
Publisher: Cambridge University Press
Print publication year: 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Asperger, H. (1944). Die “Autistischen Psychopathen” im Kindesalter. Archiv für Psychiatrie und Nervenkrankheiten, 117, 76136.Google Scholar
Baranek, G. T. (1999). Autism during infancy: A retrospective video analysis of sensory-motor and social behaviors at 9–12 months of age. Journal of Autism and Developmental Disorders, 29(3), 213224.Google Scholar
Bedford, R., Elsabbagh, M., Gliga, T., Pickles, A., Senju, A., Charman, T., & Johnson, M. (2012). Precursors to social and communication difficulties in infants at-risk for autism: Gaze following and attentional engagement. Journal of Autism and Developmental Disorders, 42(10), 22082218. doi:10.1007/s10803-012-1450-yGoogle Scholar
Bedford, R., Jones, E. J., Johnson, M. H., Pickles, A., Charman, T., & Gliga, T. (2016). Sex differences in the association between infant markers and later autistic traits. Molecular Autism, 7(1), 21.Google Scholar
Blasi, A., Lloyd-Fox, S., Sethna, V., Brammer, M. J., Mercure, E., Murray, L., … Johnson, M. H. (2015). Atypical processing of voice sounds in infants at risk for autism spectrum disorder. Cortex, 71, 122133.Google Scholar
Bölte, S., Tomalski, P., Marschik, P. B., Berggren, S., Norberg, J., Falck-Ytter, T., … Roeyers, H. (2016). Challenges and inequalities of opportunities in european psychiatry research. European Journal of Psychological Assessment, 34(4), 270277.Google Scholar
Braukmann, R., Lloyd-Fox, S., Blasi, A., Johnson, M. H., Bekkering, H., Buitelaar, J. K., & Hunnius, S. (2018). Diminished socially selective neural processing in 5-month-old infants at high familial risk of autism. European Journal of Neuroscience, 47(6), 720728.Google Scholar
Brian, J., Bryson, S. E., Garon, N., Roberts, W., Smith, I. M., Szatmari, P., & Zwaigenbaum, L. (2008). Clinical assessment of autism in high-risk 18-month-olds. Autism, 12(5), 433456. doi:10.1177/1362361308094500Google Scholar
Brisson, J., Warreyn, P., Serres, J., Foussier, S., & Adrien-Louis, J. (2012). Motor anticipation failure in infants with autism: A retrospective analysis of feeding situations. Autism, 16(4), 420429.Google Scholar
Bryson, S. E., Zwaigenbaum, L., Brian, J., Roberts, W., Szatmari, P., Rombough, V., & McDermott, C. (2007). A prospective case series of high-risk infants who developed autism. Journal of Autism and Developmental Disorders, 37(1), 1224. doi:10.1007/s10803-006-0328-2Google Scholar
Bussu, G., Jones, E. J., Charman, T., Johnson, M. H., Buitelaar, J., & Team, B. (2018). Prediction of autism at 3 years from behavioural and developmental measures in high-risk infants: A longitudinal cross-domain classifier analysis. Journal of Autism and Developmental Disorders, 48, 24182433.Google Scholar
Chawarska, K., Macari, S., & Shic, F. (2013). Decreased spontaneous attention to social scenes in 6-month-old infants later diagnosed with autism spectrum disorders. Biological Psychiatry, 74(3), 195203. doi:10.1016/j.biopsych.2012.11.022Google Scholar
Chawarska, K., Shic, F., Macari, S., Campbell, D. J., Brian, J., Landa, R., … Bryson, S. (2014). 18-month predictors of later outcomes in younger siblings of children with autism spectrum disorder: A baby siblings research consortium study. Journal of the American Academy of Child and Adolescent Psychiatry, 53(12), 13171327. doi:10.1016/j.jaac.2014.09.015Google Scholar
Clifford, S. M., Hudry, K., Elsabbagh, M., Charman, T., Johnson, M. H., & Team, B. (2013). Temperament in the first 2 years of life in infants at high-risk for autism spectrum disorders. Journal of Autism and Developmental Disorders, 43(3), 673686.CrossRefGoogle ScholarPubMed
Daluwatte, C., Miles, J., Sun, J., & Yao, G. (2015). Association between pupillary light reflex and sensory behaviors in children with autism spectrum disorders. Research in Developmental Disabilities, 37, 209215.Google Scholar
Dawson, G., Osterling, J., Meltzoff, A. N., & Kuhl, P. (2000). Case study of the development of an infant with autism from birth to two years of age. Journal of Applied Developmental Psychology, 21(3), 299313.Google Scholar
Ekberg, T. L., Falck-Ytter, T., Bölte, S., & Gredebäck, G. (2015). Reduced prospective motor control in 10-month-olds at risk for autism spectrum disorder. Clinical Psychological Science, 4(1), 129135. https://doi.org/10.1177/2167702615576697Google Scholar
Elison, J. T., Paterson, S. J., Wolff, J. J., Reznick, J. S., Sasson, N. J., Gu, H. B., … Network, I. (2013). White matter microstructure and atypical visual orienting in 7-month-olds at risk for autism. American Journal of Psychiatry, 170(8), 899908. doi:10.1176/appi.ajp.2012.12091150Google Scholar
Elsabbagh, M., Fernandes, J., Webb, S. J., Dawson, G., Charman, T., Johnson, M. H., & British Autism Study of Infant Siblings Team (2013). Disengagement of visual attention in infancy is associated with emerging autism in toddlerhood. Biological Psychiatry, 74(3), 189194. doi:10.1016/j.biopsych.2012.11.030Google Scholar
Elsabbagh, M., Gliga, T., Pickles, A., Hudry, K., Charman, T., Johnson, M. H., & Team, B. (2013). The development of face orienting mechanisms in infants at-risk for autism. Behavioural Brain Research, 251, 147154. doi:10.1016/j.bbr.2012.07.030CrossRefGoogle ScholarPubMed
Elsabbagh, M., Mercure, E., Hudry, K., Chandler, S., Pasco, G., Charman, T., … Team, B. (2012). Infant neural sensitivity to dynamic eye gaze is associated with later emerging autism. Current Biology, 22(4), 338342. doi:10.1016/j.cub.2011.12.056Google Scholar
Estes, A., Zwaigenbaum, L., Gu, H., John, T. S., Paterson, S., Elison, J. T., … Schultz, R. T. (2015). Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life. Journal of Neurodevelopmental Disorders, 7(1), 24.Google Scholar
Falck-Ytter, T., Nyström, P., Gredebäck, G., Gliga, T., Bölte, S., & Team E (2018). Reduced orienting to audiovisual synchrony in infancy predicts autism diagnosis at 3 years of age. Journal of Child Psychology and Psychiatry, 59(8), 872880. doi:10.1111/jcpp.12863Google Scholar
Falck-Ytter, T., Rehnberg, E., & Bölte, S. (2013). Lack of visual orienting to biological motion and audiovisual synchrony in 3-year-olds with autism. Plos One, 8(7). doi:e6881610.1371/journal.pone.0068816CrossRefGoogle ScholarPubMed
Flanagan, J. E., Landa, R., Bhat, A., & Bauman, M. (2012). Head lag in infants at risk for autism: A preliminary study. American Journal of Occupational Therapy, 66(5), 577585.Google Scholar
Gammer, I., Bedford, R., Elsabbagh, M., Garwood, H., Pasco, G., Tucker, L., … Team, B. (2015). Behavioural markers for autism in infancy: Scores on the Autism Observational Scale for infants in a prospective study of at-risk siblings. Infant Behavior and Development, 38, 107115.Google Scholar
Green, J., Pickles, A., Pasco, G., Bedford, R., Wan, M. W., Elsabbagh, M., … Cheung, C. (2017). Randomised trial of a parent-mediated intervention for infants at high risk for autism: Longitudinal outcomes to age 3 years. Journal of Child Psychology and Psychiatry, 58(12), 13301340.CrossRefGoogle ScholarPubMed
Hallett, V., Ronald, A., Rijsdijk, F., & Happé, F. (2012). Disentangling the associations between autistic-like and internalizing traits: A community based twin study. Journal of Abnormal Child Psychology, 40(5), 815827.Google Scholar
Haartsen, R., Jones, E. J. H., Orekhova, E., Charman, T., & Johnson, M. H. (2019), Functional EEG connectivity in infants associates with later circumscribed interests in autism: A replication study. Translational Psychiatry, 9(1), 114.Google Scholar
Hazlett, H. C., Gu, H., Munsell, B. C., Kim, S. H., Styner, M., Wolff, J. J., … Botteron, K. N. (2017). Early brain development in infants at high risk for autism spectrum disorder. Nature, 542(7641), 348351.Google Scholar
Hendry, A., Jones, E. J., Bedford, R., Gliga, T., Charman, T., & Johnson, M. H. (2018). Developmental change in look durations predicts later effortful control in toddlers at familial risk for ASD. Journal of Neurodevelopmental Disorders, 10(1), 3.Google Scholar
Hogan, A. L., Caravella, K. E., Ezell, J., Rague, L., Hills, K., & Roberts, J. E. (2017). Autism spectrum disorder symptoms in infants with fragile X syndrome: A prospective case series. Journal of Autism and Developmental Disorders, 47(6), 16281644.Google Scholar
Hoshino, Y., Kumashiro, H., Yashima, Y., Tachibana, R., Watanabe, M., & Furukawa, H. (1982). Early symptoms of autistic children and its diagnostic significance. Psychiatry and Clinical Neurosciences, 36(4), 367374.Google Scholar
Hudry, K., Chandler, S., Bedford, R., Pasco, G., Gliga, T., Elsabbagh, M., … Charman, T. (2014). Early language profiles in infants at high-risk for autism spectrum disorders. Journal of Autism and Developmental Disorders, 44(1), 154167.Google Scholar
Ibanez, L. V., Grantz, C. J., & Messinger, D. S. (2013). The development of referential communication and autism symptomatology in high-risk infants. Infancy, 18(5), 687707. doi:10.1111/j.1532-7078.2012.00142.xGoogle Scholar
Jeste, S. S., & Geschwind, D. H. (2014). Disentangling the heterogeneity of autism spectrum disorder through genetic findings. Nature Reviews Neurology, 10(2), 74.Google Scholar
Johnson, M. H. (2005). Subcortical face processing. Nature Reviews Neuroscience, 6(10), 766774.Google Scholar
Johnson, M. H., Gliga, T., Jones, E., & Charman, T. (2014). Annual research review: Infant development, autism, and ADHD – early pathways to emerging disorders. Journal of Child Psychology and Psychiatry, 56(3), 228247. https://doi.org/10.1111/jcpp.12328Google Scholar
Johnson, M. H., Jones, E. J., & Gliga, T. (2015). Brain adaptation and alternative developmental trajectories. Development and Psychopathology, 27(2), 425442.Google Scholar
Jones, E. J. H., Dawson, G., Kelly, J., Estes, A., & Jane Webb, S. (2017). Parent-delivered early intervention in infants at risk for ASD: Effects on electrophysiological and habituation measures of social attention. Autism Research, 10(5), 961972.Google Scholar
Jones, E. J. H., Dawson, G., & Webb, S. (2017). Sensory hypersensitivity predicts enhanced attention capture by faces in the early development of ASD. Developmental Cognitive Neuroscience, 29, 1120.Google Scholar
Jones, E. J. H., Gliga, T., Bedford, R., Charman, T., & Johnson, M. H. (2014). Developmental pathways to autism: A review of prospective studies of infants at risk. Neuroscience and Biobehavioral Reviews, 39, 133. doi:10.1016/j.neubiorev.2013.12.001Google Scholar
Jones, W., & Klin, A. (2013). Attention to eyes is present but in decline in 2–6-month-old infants later diagnosed with autism. Nature, 504(7480), 427. doi:10.1038/nature12715Google Scholar
Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2, 217250.Google Scholar
Kas, M. J., Glennon, J. C., Buitelaar, J., Ey, E., Biemans, B., Crawley, J., … Talpos, J. (2014). Assessing behavioural and cognitive domains of autism spectrum disorders in rodents: Current status and future perspectives. Psychopharmacology, 231(6), 11251146.Google Scholar
Keehn, B., Mueller, R. -A., & Townsend, J. (2013). Atypical attentional networks and the emergence of autism. Neuroscience and Biobehavioral Reviews, 37(2), 164183. doi:10.1016/j.neubiorev.2012.11.014Google Scholar
Kennedy, D. P., D’Onofrio, B. M., Quinn, P. D., Bölte, S., Lichtenstein, P., & Falck-Ytter, T. (2017). Genetic influence on eye movements to complex scenes at short timescales. Current Biology, 27(22), 35543560.Google Scholar
Klin, A., Lin, D. J., Gorrindo, P., Ramsay, G., & Jones, W. (2009). Two-year-olds with autism orient to non-social contingencies rather than biological motion. Nature, 459(7244), 257261.Google Scholar
Kolesnik, A. M., Jones, E. J. H., Garg, S., Green, J., Charman, T., & Johnson, M. H. (2017). Early development of infants with neurofibromatosis type 1: A case series. Molecular Autism, 8(1), 62.Google Scholar
Landa, R., & Garrett-Mayer, E. (2006). Development in infants with autism spectrum disorders: A prospective study. Journal of Child Psychology and Psychiatry, 47(6), 629638.Google Scholar
Landa, R. J., Holman, K. C., & Garrett-Mayer, E. (2007). Social and communication development in toddlers with early and later diagnosis of autism spectrum disorders. Archives of General Psychiatry, 64(7), 853864.Google Scholar
Lazenby, D. C., Sideridis, G. D., Huntington, N., Prante, M., Dale, P. S., Curtin, S., … Dobkins, K. (2016). Language differences at 12 months in infants who develop autism spectrum disorder. Journal of Autism and Developmental Disorders, 46(3), 899909.Google Scholar
Leppa, V. M., Kravitz, S. N., Martin, C. L., Andrieux, J., Le Caignec, C., Martin-Coignard, D., … Cantor, R. M. (2016). Rare inherited and de novo CNVs reveal complex contributions to ASD risk in multiplex families. American Journal of Human Genetics, 99(3), 540554.Google Scholar
Lloyd-Fox, S., Begus, K., Halliday, D., Pirazzoli, L., Blasi, A., Papademetriou, M., … Moore, S. (2017). Cortical specialisation to social stimuli from the first days to the second year of life: A rural Gambian cohort. Developmental Cognitive Neuroscience, 25, 92104.Google Scholar
Lloyd-Fox, S., Blasi, A., Elwell, C. E., Charman, T., Murphy, D., & Johnson, M. H. (2013). Reduced neural sensitivity to social stimuli in infants at risk for autism. Proceedings of the Royal Society B: Biological Sciences, 280(1758), 9. doi:10.1098/rspb.2012.3026Google Scholar
Lloyd-Fox, S., Blasi, A., Pasco, G., Gliga, T., Jones, E., Murphy, D., … Johnson, M. (2017). Cortical responses before 6 months of life associate with later autism. European Journal of Neuroscience, 47(6), 736749.Google Scholar
Macari, S. L., Campbell, D., Gengoux, G. W., Saulnier, C. A., Klin, A. J., & Chawarska, K. (2012). Predicting developmental status from 12 to 24 months in infants at risk for autism spectrum disorder: A preliminary report. Journal of Autism and Developmental Disorders, 42(12), 26362647. doi:10.1007/s10803-012-1521-0Google Scholar
Mitchell, S., Brian, J., Zwaigenbaum, L., Roberts, W., Szatmari, P., Smith, I., & Bryson, S. (2006). Early language and communication development of infants later diagnosed with autism spectrum disorder. Journal of Developmental and Behavioral Pediatrics, 27(2), S69S78.Google Scholar
Molenhuis, R. T., de Visser, L., Bruining, H., & Kas, M. J. (2014). Enhancing the value of psychiatric mouse models: Differential expression of developmental behavioral and cognitive profiles in four inbred strains of mice. European Neuropsychopharmacology, 24(6), 945954.Google Scholar
Nyström, P., Gliga, T., Nilsson Jobs, E., Gredebäck, G., Charman, T., Johnson, M., … Falck-Ytter, T. (2018). Enhanced pupillary light reflex in infancy is associated with autism diagnosis in toddlerhood. Nature Communications, 9(1). doi:10.1038/s41467-018-03985-4Google Scholar
Orekhova, E. V., Elsabbagh, M., Jones, E. J., Dawson, G., Charman, T., & Johnson, M. H. (2014). EEG hyper-connectivity in high-risk infants is associated with later autism. Journal of Neurodevelopmental Disorders, 6(1), 40.Google Scholar
Ornitz, E. M., Guthrie, D., & Farley, A. H. (1977). The early development of autistic children. Journal of Autism and Childhood Schizophrenia, 7(3), 207229.Google Scholar
Ozonoff, S., Iosif, A. M., Baguio, F., Cook, I. C., Hill, M. M., Hutman, T., … Young, G. S. (2010). A prospective study of the emergence of early behavioral signs of autism. Journal of the American Academy of Child and Adolescent Psychiatry, 49(3), 256266. doi:10.1016/j.jaac.2009.11.009Google Scholar
Paul, R., Fuerst, Y., Ramsay, G., Chawarska, K., & Klin, A. (2011). Out of the mouths of babes: Vocal production in infant siblings of children with ASD. Journal of Child Psychology and Psychiatry, 52(5), 588598.Google Scholar
Ronald, A., Edelson, L. R., Asherson, P., & Saudino, K. J. (2010). Exploring the relationship between autistic-like traits and ADHD behaviors in early childhood: Findings from a community twin study of 2-year-olds. Journal of Abnormal Child Psychology, 38(2), 185196. doi:10.1007/s10802-009-9366-5Google Scholar
Ross, R. G., Hunter, S. K., Hoffman, M. C., McCarthy, L., Chambers, B. M., Law, A. J., … Freedman, R. (2016). Perinatal phosphatidylcholine supplementation and early childhood behavior problems: Evidence for CHRNA7 moderation. American Journal of Psychiatry, 173(5), 509516.Google Scholar
Rozga, A., Hutman, T., Young, G. S., Rogers, S. J., Ozonoff, S., Dapretto, M., & Sigman, M. (2011). Behavioral profiles of affected and unaffected siblings of children with autism: Contribution of measures of mother–infant interaction and nonverbal communication. Journal of Autism and Developmental Disorders, 41(3), 287301.Google Scholar
Sacrey, L. -A. R., Zwaigenbaum, L., Bryson, S., Brian, J., Smith, I. M., Roberts, W., … Novak, C. (2015). Can parents’ concerns predict autism spectrum disorder? A prospective study of high-risk siblings from 6 to 36 months of age. Journal of the American Academy of Child and Adolescent Psychiatry, 54(6), 470478.CrossRefGoogle ScholarPubMed
Shen, M. D., Kim, S. H., McKinstry, R. C., Gu, H., Hazlett, H. C., Nordahl, C. W., … Swanson, M. R. (2017). Increased extra-axial cerebrospinal fluid in high-risk infants who later develop autism. Biological Psychiatry, 82(3), 186193.Google Scholar
Shen, M. D., Nordahl, C. W., Young, G. S., Wootton-Gorges, S. L., Lee, A., Liston, S. E., … Amaral, D. G. (2013). Early brain enlargement and elevated extra-axial fluid in infants who develop autism spectrum disorder. Brain, 136(9), 28252835.Google Scholar
Shephard, E., Bedford, R., Milosavljevic, B., Gliga, T., Jones, E. J. H., Pickles, A., … Bolton, P. (2019). Early developmental pathways to childhood symptoms of attention-deficit hyperactivity disorder, anxiety and autism spectrum disorder. Journal of Child Psychology and Psychiatry, 60(9), 963974.Google Scholar
St. John, T., Estes, A. M., Dager, S. R., Kostopoulos, P., Wolff, J. J., Pandey, J., … Botteron, K. (2016). Emerging executive functioning and motor development in infants at high and low risk for autism spectrum disorder. Frontiers in Psychology, 7, 1016.Google Scholar
Sullivan, M., Finelli, J., Marvin, A., Garrett-Mayer, E., Bauman, M., & Landa, R. (2007). Response to joint attention in toddlers at risk for autism spectrum disorder: A prospective study. Journal of Autism And Developmental Disorders, 37(1), 37.Google Scholar
Swanson, M. R., Shen, M. D., Wolff, J. J., Elison, J. T., Emerson, R. W., Styner, M. A., … Paterson, S. (2017). Subcortical brain and behavior phenotypes differentiate infants with autism versus language delay. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2(8), 664672.Google Scholar
Thorup, E., Nystrom, P., Gredeback, G., Bölte, S., Falck-Ytter, T., & EASE Team (2018). Reduced alternating gaze during social interaction in infancy is associated with elevated symptoms of autism in toddlerhood. Journal of Abnormal Child Psychology, 46(7), 15471561.Google Scholar
Varcin, K. J., & Jeste, S. S. (2017). The emergence of autism spectrum disorder: Insights gained from studies of brain and behaviour in high-risk infants. Current Opinion in Psychiatry, 30(2), 8591.Google Scholar
Wan, M. W., Green, J., Elsabbagh, M., Johnson, M., Charman, T., & Plummer, F. (2013). Quality of interaction between at-risk infants and caregiver at 12–15 months is associated with 3-year autism outcome. Journal of Child Psychology and Psychiatry, 54(7), 763771.Google Scholar
Wass, S. V., Jones, E. J. H., Gliga, T., Smith, T. J., Charman, T., & Johnson, M. H. (2015). Shorter spontaneous fixation durations in infants with later emerging autism. Scientific Reports, 5, 8284. doi:10.1038/srep08284Google Scholar
Webb, S. J., Nalty, T., Munson, J., Brock, C., Abbott, R., & Dawson, G. (2007). Rate of head circumference growth as a function of autism diagnosis and history of autistic regression. Journal of Child Neurology, 22(10), 11821190.Google Scholar
West, K. L., Leezenbaum, N. B., Northrup, J. B., & Iverson, J. M. (2019). The relation between walking and language in infant siblings of children with autism spectrum disorder. Child Development, 90(3), e356e372.Google Scholar
Wolff, J. J., Jacob, S., & Elison, J. T. (2018). The journey to autism: Insights from neuroimaging studies of infants and toddlers. Development And Psychopathology, 30(2), 479495.Google Scholar
Wolff, J. J., Swanson, M. R., Elison, J. T., Gerig, G., Pruett, J. R., Styner, M. A., … Estes, A. M. (2017). Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism. Molecular Autism, 8(1), 8.Google Scholar
Yoder, P., Stone, W. L., Walden, T., & Malesa, E. (2009). Predicting social impairment and ASD diagnosis in younger siblings of children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 39(10), 13811391. doi:10.1007/s10803-009-0753-0Google Scholar
Zwaigenbaum, L., Bryson, S., Rogers, T., Roberts, W., Brian, J., & Szatmari, P. (2005). Behavioral manifestations of autism in the first year of life. International Journal Of Developmental Neuroscience, 23(2–3), 143152.Google Scholar
Zwaigenbaum, L., Thurm, A., Stone, W., Baranek, G., Bryson, S., Iverson, J., … Sigman, M. (2007). Studying the emergence of autism spectrum disorders in high-risk infants: Methodological and practical issues. Journal of Autism and Developmental Disorders, 37(3), 466480.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×