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2a - Four Key Areas for Further Investigation: Commentary on Issues and New Directions in Personality Disorder Genetics

from Part I - Etiology

Published online by Cambridge University Press:  24 February 2020

By
William Calabrese ,
Maria Martin Lopez ,
Jacqueline Trumbull ,
Sarah B. Rutter  and
M. Mercedes Perez-Rodriguez
Edited by
Carl W. Lejuez  and
Kim L. Gratz
Carl W. Lejuez
Affiliation:
University of Kansas
Kim L. Gratz
Affiliation:
University of Toledo, Ohio
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Summary

The following commentary on Jang and Choi’s chapter Issues and New Directions in Personality Disorder (PD) Genetics (This Volume) echoes their call to harness advances in PD assessment rather than rely on politically derived "top down" nosologies. We first discuss how recent work in the joint hierarchical structure of PD traits and psychopathology, as well as, personality dynamics (i.e., how personality manifests in different situations) likely offer fruitful avenues for exploring the more nuanced role of genetics in the development and maintenance of PD. Second, we highlight the need to better understand the role of environment in PD genetics and discuss emerging models (e.g., common pathway model). Third, we stress the need for more research and larger samples in order to arrive at stronger conclusions. Fourth, we consider how advances in gene-environment research can help to determine targets for PD prevention and treatment.

Keywords

hierarchical taxonomy of psychopathologypersonality dynamicscommon pathway modelintermediate phenotypesexposome
Type
Chapter
Information
The Cambridge Handbook of Personality Disorders , pp. 40 - 43
Publisher: Cambridge University Press
Print publication year: 2020

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