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1c - Illustrating the Value of Neuroimaging Studies Using the Example of Affect Regulation: Author Rejoinder to Commentaries on Neuroimaging in Personality Disorders

from Part I - Etiology

Published online by Cambridge University Press:  24 February 2020

By
Chi C. Chan ,
Daniel H. Vaccaro ,
Nina L. J. Rose ,
Laura E. Kessler  and
Erin A. Hazlett
Edited by
Carl W. Lejuez  and
Kim L. Gratz
Carl W. Lejuez
Affiliation:
University of Kansas
Kim L. Gratz
Affiliation:
University of Toledo, Ohio
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Summary

This rejoinder uses the neuroimaging literature on affect regulation to exemplify how integration of complementary methods suggested by the commentaries could advance neurobiological understanding of personality disorders. It illustrates progressive insights gained from incorporating multiple sources of evidence including neuroimaging, genetics, and behavioral data associated with affect regulation. It also demonstrates the use of brain pattern activation analysis in addition to studying individual regions of interest to better understand the complex relationships between biological genotype, brain activity, and behavioral phenotype. The ways in which neuroimaging can serve as an endophenotype to bridge the gap between genes and distant phenotypes are highlighted.

Keywords

neuroimagingaffect regulationenodophenotypegenesphenotype5-HTTLPRpersonality disorders
Type
Chapter
Information
The Cambridge Handbook of Personality Disorders , pp. 27 - 28
Publisher: Cambridge University Press
Print publication year: 2020

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References

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