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Case 4 - “I Am Tired All the Time”

Dementia with Lewy Bodies

Published online by Cambridge University Press:  31 October 2024

Matthew Gibfried  and
George T. Grossberg
Matthew Gibfried
Affiliation:
Saint Louis University School of Medicine, Missouri
George T. Grossberg
Affiliation:
Saint Louis University School of Medicine, Missouri
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Summary

Dementia with Lewy bodies (DLB) is a neurodegenerative disorder characterized by the presence of Lewy bodies, which are abnormal protein deposits, in certain areas of the brain. The symptoms of DLB can be variable and fluctuate from day to day, making it challenging to diagnose. The most common symptom is cognitive impairment. There are central features, core features, suggestive features, and supportive features that can be used to aid in the diagnosis of DLB. REM sleep behavior disorder is common in DLB and Parkinson-related dementia.

Keywords

dementia with Lewy bodiesLewy body dementiaREM sleep behavior disorderParkinson’s disease dementia
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Clinical Case Studies in Long-Term Care Psychiatry
Navigating Common Mental Health Challenges in Geriatric Care
 , pp. 16 - 19
Publisher: Cambridge University Press
Print publication year: 2024

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References

Further Reading

American Psychiatric Association. (2022). Diagnostic and Statistical Manual of Mental Disorders. 5th ed. text rev. (American Psychiatric Association Publishing).Google Scholar
Cummings, J., Isaacson, S., Mills, R., Williams, H., Chi-Burris, K., Corbett, A., Dhall, R., & Ballard, C. (2014). Pimavanserin for patients with Parkinson’s disease psychosis: A randomized, placebo-controlled phase 3 trial. Lancet, 383, 533–540.CrossRefGoogle Scholar
Desai, A., & Grossberg, G. (2018). Psychiatric Consultation in Long-Term Care. A Guide for Healthcare Professionals. 2nd ed. (Cambridge University Press). pp. 51–53.Google Scholar
Emre, M., Aarsland, D., Brown, R., Burn, D. J., Duyckaerts, C., Mizuno, Y., Broe, G. A., Cummings, J., Dickson, D. W., Gauthier, S., Goldman, J., Goetz, C., Korczyn, A., Lees, A., Levy, R., Litvan, I., McKeith, I., Olanow, W., Poewe, W., Quinn, N., Sampaio, C., Tolosa, E., & Dubois, B. (2007). Clinical diagnostic criteria for dementia associated with Parkinson’s disease. Movement Disorders, 22 (12), 1689–1707; quiz 1837. doi: 10.1002/mds.21507. PMID: 17542011.CrossRefGoogle ScholarPubMed
Haider, A., Spurling, B. C., & Sánchez-Manso, J. C. (2023). Lewy body dementia. [Updated February 12]. In StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing. www.ncbi.nlm.nih.gov/books/NBK482441/Google Scholar
Outeiro, T. F., Koss, D. J., Erskine, D., Walker, L., Kurzawa-Akanbi, M., Burn, D., Donaghy, P., Morris, C., Taylor, J. P., Thomas, A., Attems, J., & McKeith, I. (2019). Dementia with Lewy bodies: An update and outlook. Molecular Neurodegeneration, 14 (1), 5. doi: 10.1186/s13024-019-0306-8. PMID: 30665447; PMCID: PMC6341685.CrossRefGoogle ScholarPubMed
Smith, G. E., Boeve, B., Pankratz, S., Jacobson, K., Aakre, J., & Tanis, F. (2009). Time course of diagnostic features of Lewy body disease. Neurology, 72 (11), A246–A246, 530.Google Scholar
Tariot, P. N., Cummings, J. L., Soto-Martin, M. E., Ballard, C., Erten-Lyons, D., Sultzer, D. L., Devanand, D. P., Weintraub, D., McEvoy, B., Youakim, J. M., Stankovic, S., & Foff, E. P. (2021). Trial of pimavanserin in dementia-related psychosis. New England Journal of Medicine, 385 (4), 309–319. doi: 10.1056/NEJMoa2034634. PMID: 34289275.CrossRefGoogle ScholarPubMed
Vann Jones, S. A., & O’Brien, J. T. (2014). The prevalence and incidence of dementia with Lewy bodies: A systematic review of population and clinical studies. Psychological Medicine, 44 (4), 673–683. doi: 10.1017/S0033291713000494. Epub 2013 Mar 25. Erratum in: Psychol Med. 2014 Mar;44(4):684. PMID: 23521899.CrossRefGoogle ScholarPubMed

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  • “I Am Tired All the Time”
  • Matthew Gibfried, Saint Louis University School of Medicine, Missouri, George T. Grossberg, Saint Louis University School of Medicine, Missouri
  • Book: Clinical Case Studies in Long-Term Care Psychiatry
  • Online publication: 31 October 2024
  • Chapter DOI: https://doi.org/10.1017/9781108630344.005
Available formats
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Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • “I Am Tired All the Time”
  • Matthew Gibfried, Saint Louis University School of Medicine, Missouri, George T. Grossberg, Saint Louis University School of Medicine, Missouri
  • Book: Clinical Case Studies in Long-Term Care Psychiatry
  • Online publication: 31 October 2024
  • Chapter DOI: https://doi.org/10.1017/9781108630344.005
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • “I Am Tired All the Time”
  • Matthew Gibfried, Saint Louis University School of Medicine, Missouri, George T. Grossberg, Saint Louis University School of Medicine, Missouri
  • Book: Clinical Case Studies in Long-Term Care Psychiatry
  • Online publication: 31 October 2024
  • Chapter DOI: https://doi.org/10.1017/9781108630344.005
Available formats
×