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Clinical Case Studies in Long-Term Care Psychiatry Clozapine
Published online by Cambridge University Press: 31 October 2024
Clozapine is now an important medication in the treatment of schizophrenia. It is used primarily in cases of treatment-resistant schizophrenia but is also useful in patients with schizophrenia that have had adverse effects to multiple other antipsychotics. The use of clozapine in schizophrenia has several benefits in addition to improving the control of the symptoms of schizophrenia for those with treatment-resistant schizophrenia. The risks of using clozapine are well known and the most feared side effect of clozapine is agranulocytosis. Agranulocytosis risk is highest in the first three months of use of the drug but is possible even after years of use. There are some off-label uses of clozapine that healthcare providers in long-term care should be aware of. Some studies have suggested that clozapine may be effective in treating treatment-resistant depression. Clozapine has been used off-label in the treatment of bipolar disorder, particularly in people who have not responded to other more commonly prescribed medications.
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