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Chapter 8 - Neuroinflammation and Staging

from Section 2 - Progress with Clinical Staging

Published online by Cambridge University Press:  08 August 2019

By
Bernhard T. Baune
Edited by
Patrick D. McGorry  and
Ian B. Hickie
Patrick D. McGorry
Affiliation:
University of Melbourne
Ian B. Hickie
Affiliation:
University of Sydney
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Summary

The staging model of mental illness is developing beyond the clinical level aiming to include biological processes and markers that may reflect the dynamic biological processes of stages of mental illness. The neurobiology of inflammation in mental illness has gained much attention in recent years. Since neuroinflammation has been shown to be an important possible feature of psychosis, schizophrenia and depression, in this chapter it is attempted to map changes and dysregulation of the immune system and inflammation to the different clinical stages of severe mental illness. The literature suggests that an increased inflammatory response may define a subgroup of individuals in ultra-high-risk states, in acute disease episodes and in those with severe mental illness. In addition, the literature clearly points to the dynamic nature of the immune response in mental illness and shows an involvement of both the innate and adaptive immune system in mental illness. A focus on inflammation only might be insufficient and a broader understanding of the interaction between innate and adaptive immune systems and the complex neuroimmune interaction is required.

Keywords

clinical stagingmental disordersbiological makersneuroinflammationinflammationoxidative stressneuroprotectionomega-3 fatty acidsdiagnosisintervention
Type
Chapter
Information
Clinical Staging in Psychiatry
Making Diagnosis Work for Research and Treatment
 , pp. 172 - 190
Publisher: Cambridge University Press
Print publication year: 2019

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