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Chapter 10 - Mood Disorders and Stress-Related Disorders

Published online by Cambridge University Press:  16 May 2024

By
Romayne Gadelrab  and
Mario Juruena
Edited by
Allan Young ,
Marsal Sanches ,
Jair C. Soares  and
Mario Juruena
Allan Young
Affiliation:
Institute of Psychiatry, King's College London
Marsal Sanches
Affiliation:
Baylor College of Medicine, Texas
Jair C. Soares
Affiliation:
McGovern Medical School, The University of Texas
Mario Juruena
Affiliation:
King's College London
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Summary

This chapter outlines the current research on the stress response and how chronic stress can lead to the dysfunction of neuroendocrine and immune responses and ultimately contribute to the development of psychiatric disorders. The chapter aims to provide an understanding of the pathways involved in the stress response, in particular the HPA axis and the role of cortisol, exploring the role of HPA hyperactivity as a contributor to major depressive disorder. The chapter reviews the impact of the stress response in bipolar and post-traumatic stress disorder, concluding with a summary of our current understanding of the interplay of mood disorders with early life stress.

Keywords

mood disordersdepressionbipolarstressneuroendocrineimmune responseHPA-axispost-traumatic stressearly-life stresschronic stress, cortisol
Type
Chapter
Information
Clinical Textbook of Mood Disorders , pp. 103 - 115
Publisher: Cambridge University Press
Print publication year: 2024

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