Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-26T06:06:41.188Z Has data issue: false hasContentIssue false

Chapter 17 - Thyroid dysfunction and critical care

from Section 3 - Endocrine disorders in the critically ill

Published online by Cambridge University Press:  06 July 2010

By
Brian Mullan
Edited by
George M. Hall ,
Jennifer M. Hunter  and
Mark S. Cooper
George M. Hall
Affiliation:
St George's Hospital, London
Jennifer M. Hunter
Affiliation:
University of Liverpool
Mark S. Cooper
Affiliation:
University of Birmingham
Get access

Summary

Thyroid hormone is essential for the regulation of tissue metabolism. Thyrotropin releasing hormone is a tripeptide which is produced in the parvocellular region of the paraventricular nuclei of the hypothalamus. A wide variety of medications which may be used during critical illness can affect thyroid hormone physiology and the interpretation of thyroid function tests. Hyperthyroidism is the consequence of excessive thyroid hormone action. Hypothyroidism results from under secretion of thyroid hormone from the thyroid gland. It can be classified as primary, secondary and tertiary. The most common cause of primary hypothyroidism is chronic autoimmune thyroiditis. Other causes include surgical removal of the thyroid gland, thyroid gland ablation with radioactive iodine, infiltrative diseases, iodine deficiency, congenital enzymatic defects which affect thyroid hormone synthesis and drug-induced effects. Secondary and tertiary hypothyroidisms are usually due to pituitary and hypothalamic disorders respectively.

Keywords

biguanidesdiabetes mellitusglucosidase inhibitorssulphonylureassynthetic amylin analoguesreceptor agonistsmeglitinidesinhibitorsthiazolidinediones
Type
Chapter
Information
Core Topics in Endocrinology in Anaesthesia and Critical Care , pp. 168 - 174
Publisher: Cambridge University Press
Print publication year: 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×