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Chapter 8 - Risk Factors and Non-Pharmacological Prevention of Dementia

Published online by Cambridge University Press:  26 May 2022

By
Rudi D’Hooge ,
Ann Van der Jeugd ,
Sebastiaan Engelborghs ,
Frans Boch Waldorff  and
Mathieu Vandenbulcke
Edited by
Mathieu Vandenbulcke ,
Rose-Marie Dröes  and
Erik Schokkaert
Mathieu Vandenbulcke
Affiliation:
KU Leuven, Belgium
Rose-Marie Dröes
Affiliation:
Amsterdam University Medical Centre
Erik Schokkaert
Affiliation:
KU Leuven, Belgium
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Summary

A life-course approach to enhance tolerance to and prevent dementia and senescence is increasingly embraced by scientists, clinicians and policy makers to promote healthy ageing. Tolerance enhancement and prevention remain the most sensible courses of action given the lack of effective dementia treatment. We discuss the modifiable risk factors of dementia, and address social isolation and loneliness in view of their importance from a psychological and societal perspective. The effectiveness of prevention strategies and non-pharmacological intervention is increasingly supported by scientific evidence. They support an actionable model of dementia and senescence prevention that is cost effective and converges with established public health programmes (diet, exercise, mental health). They also relate to central societal issues (social inequality, pollution, healthcare), and translate to multidisciplinary professional interventions that are tailored to the individual. Changing lifestyle might be an effective way to address the challenges of dementia and senescence in our ageing populations, but also represents one of the most formidable psychosocial and societal challenges.

Keywords

dementiasenescencemodifiable risk factorstolerancenon-pharmacological preventionlifestyle changes
Type
Chapter
Information
Dementia and Society , pp. 153 - 166
Publisher: Cambridge University Press
Print publication year: 2022

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References

Shah, H, Albanese, E, Duggan, C, Rudan, I, Langa, KM, Carrillo, MC, et al. Research priorities to reduce the global burden of dementia by 2025. Lancet Neurol. 2016; 15: 1285–94.CrossRefGoogle ScholarPubMed
Christensen, K, Thinggaard, M, Oksuzyan, A, Steenstrup, T, Andersen-Ranberg, K, Jeune, B, et al. Physical and cognitive functioning of people older than 90 years: A comparison of two Danish cohorts born 10 years apart. Lancet 2013; 382: 1507–13.CrossRefGoogle Scholar
Warner, H, Anderson, J, Austad, S, Bergamini, E, Bredesen, D, Butler, R, et al. Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep. 2005; 6: 1006–8.CrossRefGoogle ScholarPubMed
Vijg, J, Campisi, J. Puzzles, promises and a cure for ageing. Nature 2008; 454: 1065–71.CrossRefGoogle Scholar
Christensen, K, Doblhammer, G, Rau, R, Vaupel, JW. Ageing populations: The challenges ahead. Lancet 2009; 374: 1196–1208.CrossRefGoogle ScholarPubMed
Yaffe, K, Hoang, T. Nonpharmacologic treatment and prevention strategies for dementia. Continuum 2013; 19: 372–81.Google ScholarPubMed
Livingston, G, Sommerlad, A, Orgeta, V, Costafreda, SG, Huntley, J, Ames, D, et al. Dementia prevention, intervention, and care. Lancet 2017; 390: 2673–2734.CrossRefGoogle ScholarPubMed
Livingston, G, Huntley, J, Sommerlad, A, Ames, D, Ballard, C, Banerjee, S, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet 2020; 396: 413–44.CrossRefGoogle ScholarPubMed
Clare, L, Wu, Y-T, Teale, JC, MacLeod, C, Matthews, F, Brayne, C, et al. Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study. PLoS Med 2017; 14: e1002259.CrossRefGoogle ScholarPubMed
Wu, YT, Beiser, AS, Breteler, MMB, Fratiglioni, L, Helmer, C, Hendrie, HC, et al. The changing prevalence and incidence of dementia over time: Current evidence. Nat Rev Neurol. 2017; 13: 327–39.CrossRefGoogle ScholarPubMed
Donovan, NJ, Okereke, OI, Vannini, P, Amariglio, RE, Rentz, DM, Marshall, GA, et al. Association of higher cortical amyloid burden with loneliness in cognitively normal older adults. JAMA Psychiatry 2016; 73: 1230–7.CrossRefGoogle ScholarPubMed
De Jong-Gierveld, J. A review of loneliness: Concepts and definitions, determinants and consequences. Rev Clin Gerontol. 1998; 8: 73–80.CrossRefGoogle Scholar
Beller, J, Wagner, A. Loneliness, social isolation, their synergistic interaction, and mortality. Health Psychol. 2018; 37: 808–13.CrossRefGoogle ScholarPubMed
Cacioppo, JT, Hawkley, LC, Norman, GJ, Berntson, GG Social isolation. Ann N Y Acad Sci. 2011; 1231(1): 17–22.CrossRefGoogle ScholarPubMed
Cacioppo, JT, Hawkley, LC. Perceived social isolation and cognition. Trends Cogn Sci. 2009; 13: 447–54.CrossRefGoogle ScholarPubMed
Spithoven, AWM, Bijttebier, P, Goossens, L. It is all in their mind: A review on information processing bias in lonely individuals. Clin Psychol Rev. 2017; 58: 97–114.CrossRefGoogle ScholarPubMed
Eisenberger, NI, Lieberman, MD, Williams, KD. Does rejection hurt? An fMRI study of social exclusion. Science 2003; 302: 290–2.CrossRefGoogle ScholarPubMed
Grand, JH, Caspar, S, Macdonald, SW. Clinical features and multidisciplinary approaches to dementia care. J Multidiscip Healthcare 2011; 4: 125–47.Google ScholarPubMed
Sørensen, LV, Waldorff, FB, Waldemar, G. Early counselling and support for patients with mild Alzheimer’s disease and their caregivers: A qualitative study on outcome. Aging Ment Health 2008; 12(4): 444–50.CrossRefGoogle ScholarPubMed
Sørensen, LV, Waldorff, FB, Waldemar, G. Coping with mild Alzheimer’s disease. Dementia 2008; 7: 187–99.CrossRefGoogle Scholar
Due, TD, Sandholdt, H, Siersma, VD, Waldorff, FB. How well do general practitioners know their elderly patients’ social relations and feelings of loneliness? BMC Fam Pract. 2018; 19(1): art. 34.CrossRefGoogle ScholarPubMed
Martins, C, Godycki-Cwirko, M, Heleno, B, Brodersen, J. Quaternary prevention: Reviewing the concept. Eur J Gen Pract. 2018; 24: 106–11.CrossRefGoogle ScholarPubMed
Honig, LS, Vellas, B, Woodward, M, Boada, M, Bullock, R, Borrie, M, et al. Trial of solanezumab for mild dementia due to Alzheimer’s disease. N Engl J Med. 2018; 378: 321–30.CrossRefGoogle ScholarPubMed
Colantuoni, E, Surplus, G, Hackman, A, Arrighi, HM, Brookmeyer, R. Web-based application to project the burden of Alzheimer’s disease. Alzheimers Dement. 2010; 6(5): 425–8.CrossRefGoogle Scholar
Greene, C, Lee, H, Thuret, S. In the long run: Physical activity in early life and cognitive aging. Front Neurosci. 2019; 13: art. 884.CrossRefGoogle Scholar
Vemuri, P, Lesnick, TG, Przybelski, SA, Machulda, M, Knopman, DS, Mielke, MM, et al. Association of lifetime intellectual enrichment with cognitive decline in the older population. JAMA Neurol. 2014; 71: 1017–24.CrossRefGoogle ScholarPubMed
Alves, J, Magalhães, R, Thomas, RE, Gonçalves, OF, Petrosyan, A, Sampaio, A. Is there evidence for cognitive intervention in Alzheimer disease? A systematic review of efficacy, feasibility, and cost-effectiveness. Alzheimer Dis Assoc Disord. 2013; 27: 195–203.CrossRefGoogle ScholarPubMed
Carrion, C, Folkvord, F, Anastasiadou, D, Aymerich, M. Cognitive therapy for dementia patients: A systematic review. Dement Geriatr Cogn Disord. 2018; 46: 1–26.CrossRefGoogle ScholarPubMed
Bredesen, DE. Reversal of cognitive decline: A novel therapeutic program. Aging 2014; 6: 707–17.CrossRefGoogle ScholarPubMed
Bredesen, DE, Amos, EC, Canick, J, Ackerley, M, Raji, C, Fiala, M, Ahdidan, J. Reversal of cognitive decline in Alzheimer’s disease. Aging 2016; 8: 1250–8.CrossRefGoogle ScholarPubMed
Reuter-Lorenz, PA, Park, DC. How does it STAC up? Revisiting the scaffolding theory of aging and cognition. Neuropsychol Rev. 2014; 24: 355–70.CrossRefGoogle ScholarPubMed
Cornaro, L. The Art of Living Long: A New and Improved English Version. Milwaukee, WI, William F. Butler, 1915.Google Scholar
Hall, KD, Khan, S. Maintenance of lost weight and long-term management of obesity. Med Clin North Am. 2019; 102: 183–97.Google Scholar
Sommerlad, A, Sabia, S, Livingston, G, Kivimäki, M, Lewis, G, Singh-Manoux, A. Leisure activity participation and risk of dementia: An 18-year follow-up of the Whitehall II Study. Neurology 2020; 95: e2803–e2815.CrossRefGoogle ScholarPubMed

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