Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-10T17:11:04.076Z Has data issue: false hasContentIssue false

Chapter 17 - Metastatic Lesions

Published online by Cambridge University Press:  12 November 2020

Jon van der Walt
Affiliation:
St Thomas’ Hospital, London
Attilio Orazi
Affiliation:
Texas Tech University
Daniel A. Arber
Affiliation:
University of Chicago
Get access

Summary

The bone marrow (BM) is a frequent site of haematogenous spread for all types of cancer. Metastatic spread of disseminated tumour cells (DTCs) to the BM is detected in 0.2 to 12% of patients with solid tumours [1]. The variability in incidence is related to the incidence of the primary tumour and its homing behaviour [2]. Common primary tumours affecting the BM are listed below (Table 17.1).

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Filanovsky, K, Feldberg, E, Miller, EB. Predictive value of clinical and laboratory parameters for overt bone marrow metastasis in patients with solid malignancies. J Cancer Therapy. 2017;8(8), 773–84.CrossRefGoogle Scholar
Foucar, K, Richard, K, Czuchlewski, D. Bone Marrow Pathology. 3rd ed. Chicago, IL: ASCP; 2010: 657659.Google Scholar
Munive, CO, Muro, MF, Ferreyros, G, et al. Outcome of breast cancer with symptomatic bone marrow involvement. J Clin Oncol. 2015;33,15 Suppl.Google Scholar
Joosse, SA, Gorges, TM, Pantel, K. Biology, detection, and clinical implications of circulating tumor cells. EMBO Mol Med. 2014;7(1):111.Google Scholar
Alix-Panabières, C, Riethdorf, S, Pantel, K. Circulating tumor cells and bone marrow micrometastasis. Clin Cancer Res. 2008;14(16):5113–21.CrossRefGoogle ScholarPubMed
Cotta, CV, Konoplev, S, Medeiros, LJ, Bueso-Ramos, CE. Metastatic tumours in the bone marrow: histopathology and advances in the biology of the tumour cells and the bone marrow enviroment. Ann Diagn Pathol. 2006;10:169–92.CrossRefGoogle Scholar
Shiozawa, Y, Havens, AM, Pienta, KJ, Taichman, RS. The bone marrow niche: habitat to hematopoeitic and mesenchymal stem cells, and unwitting host to molecular parasites. Leukemia. 2008;22:941–50.Google Scholar
Bain, BJ, Clark, DM, Wilkins, BS. Bone Marrow Pathology, 4th edn. Wiley; 2011: 549586.Google Scholar
Bain, BJ. Pathology of the bone marrow. In: Porwit, A, McCullough, J, Erber, WN. (Eds) Blood and Bone Marrow Pathology. Elsevier Ltd; 2011: 79104.Google Scholar
Bedolla, G, Stemmerman, G. Pulmonary small cell carcinocythaemia. Lancet. 2003;361(9375):2193–66.Google Scholar
Bain, BJ. Blood Cells: A Practical Guide, 5th edn. Wiley-Blackwell; 2015.Google Scholar
Sailer, V, Schiffman, MH, Kossai, M, et al. Bone biopsy protocol for advanced prostate cancer in the era of precision medicine. Cancer. 2018;124(5):1008–15.Google Scholar
Proytcheva, M. Pediatric small blue cell tumors metastatic to the bone marrow. In Proytcheva, M (Ed.), Diagnostic Pediatric Hematopathology. Cambridge: Cambridge University Press; 2011: 379394.Google Scholar
Alix-Panabier̀es, C, Pantel, K. Circulating tumor cells: liquid biopsy of cancer. Clin Chem. 2013;59(1):110–18.Google Scholar
Masuda, T, Hayashi, N, Iguchi, T, et al. Clinical and biological significance of circulating tumor cells in cancer. Molec Oncol. 2016;10(3):408–17.Google Scholar
Łukaszewski, B, Nazar, J, Goch, M, et al. Diagnostic methods for detection of bone metastases. Contemp Oncol. 2017;21(2):98103.Google Scholar
Banys-Paluchowski, M, Krawczyk, N, Fehm, T. Potential role of circulating tumor cell detection and monitoring in breast cancer: a review of current evidence. Front Oncol. 2016;6.Google Scholar
Hegemann, M, Stenzl, A, Bedke, J, et al. Liquid biopsy: ready to guide therapy in advanced prostate cancer? BJU Int. 2016;118(6):855–63.Google Scholar
Page, K, Guttery, DS, Fernandez-Garcia, D, et al. Next generation sequencing of circulating cell-free DNA for evaluating mutations and gene amplification in metastatic breast cancer. Clin Chem. 2017;63(2):532–41.Google Scholar
Oellerich, M, Schütz, E, Beck, J, et al. Using circulating cell-free DNA to monitor personalized cancer therapy. Crit Rev Clin Lab Sci. 2017;54(3):205–18.Google Scholar
Hartkopf, AD, Wallwiener, M, Fehm, TN, et al. Disseminated tumor cells from the bone marrow of patients with nonmetastatic primary breast cancer are predictive of locoregional relapse. Ann Oncol. 2015;26(6):1155–60.Google Scholar
Zhou, L, Dicker, DT, Matthew, E, El-Deiry, WS, Alpaugh, RK. Circulating tumor cells: silent predictors of metastasis. F1000Res. 2017;6:ii.Google Scholar
Łukaszewski, B, Nazar, J, Goch, M, et al. Diagnostic methods for detection of bone metastases. Contemp Oncol. 2017;21(2):98103.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×