Skip to main content Accessibility help
×
Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-26T19:16:46.274Z Has data issue: false hasContentIssue false

Chapter 2 - The Normal Bone Marrow

Published online by Cambridge University Press:  12 November 2020

Jon van der Walt
Affiliation:
St Thomas’ Hospital, London
Attilio Orazi
Affiliation:
Texas Tech University
Daniel A. Arber
Affiliation:
University of Chicago
Get access

Summary

Knowledge and understanding of the appearance of normal bone marrow (BM) and therefore normal haematopoiesis is essential for both general pathologists and specialist haematopathologists. It is only once normal cytology and histology is understood that abnormalities can be identified and defined, leading to the accurate diagnosis of pathologies seen in the BM.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Pearsall, J (ed) The Concise Oxford Dictionary, 10th edn. Oxford University Press; 2001.Google Scholar
Gale, E, Torrance, J, Bothwell, T. The quantitative estimation of total iron stores in human bone marrow. J Clin Invest. 1963;42:1076–82.Google Scholar
Bryder, D, Rossi, DJ, Weissman, IL. Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol. 2006;169(2):338–46.Google Scholar
Wilkins, BS. Histology of normal haemopoiesis: bone marrow histology. Int J Clin Pathol. 1992;45(8):645–9.Google Scholar
Porwit, A, McCullough, J, Erber, WN (eds) Blood and Bone Marrow Pathology, 2nd edn. Elsevier; 2011.Google Scholar
Bain, BJ. A fat cell in a bone marrow aspirate. Am J Hematol. 2011;86(1):66.CrossRefGoogle Scholar
Bain, BJ. The bone marrow aspirate of healthy subjects. Br J Haematol. 1996;94(1):206–9.Google Scholar
Stevens, A, Lowe, JS. Human Histology, 2nd edn. Mosby; 2000.Google Scholar
Brown, DC, Gatter, KC. The bone marrow trephine biopsy: a review of normal histology. Histopathology. 1993;22(5):411–22.Google Scholar
Geddis, AE. Megakaryopoiesis. Semin Hematol. 2010;47(3):212–19.Google Scholar
Bain, BJ. What is a promonocyte? Am J Hematol. 2013;88(10):919.Google Scholar
Goasguen, JE, Bennett, JM, Bain, BJ, et al. International Working Group on Morphology of Myelodysplastic Syndrome. Morphological evaluation of monocytes and their precursors. Haematologica. 2009;94(7):994–7.CrossRefGoogle Scholar
Thaler, J, Greil, R, Dietze, O, Huber, H. Immunohistology for quantification of normal bone marrow lymphocyte subsets. Br J Haematol. 1989;73(4):576–7.Google Scholar
Horny, HP, Wehrmann, M, Griesser, H, et al. Investigation of bone marrow lymphocyte subsets in normal, reactive, and neoplastic states using paraffin-embedded biopsy specimens. Am J Clin Pathol. 1993;99(2):142–9.Google Scholar
Foucar, K, Reichard, K, Czuchlewski, D. Bone Marrow Pathology, 3rd edn. ASCP Press; 2010.Google Scholar
Rego, EM, Garcia, AB, Viana, SR, Falcão, RP. Age-related changes of lymphocyte subsets in normal bone marrow biopsies. Cytometry. 1998;34(1):22–9.3.0.CO;2-G>CrossRefGoogle Scholar
Hartsock, RJ, Smith, EB, Petty, CS. Normal variations with aging of the amount of hematopoietic tissue in bone marrow from the anterior iliac crest. A study made from 177 cases of sudden death examined by necropsy. Am J Clin Pathol. 1965;43:326–31.Google Scholar
Verma, S, Rajaratnam, JH, Denton, J, Hoyland, JA, Byers, RJ. Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol. 2002;55(9):693–8.Google Scholar
Lamberts, SW, van den Beld, AW, van der Lely, AJ. The endocrinology of aging. Science. 1997;278(5337):419–24.CrossRefGoogle ScholarPubMed
Prabhakar, M, Ershler, WB, Longo, DL. Bone marrow, thymus and blood: changes across the lifespan. Aging Health. 2009;5(3):385–93.Google Scholar
Hoffbrand, V, Catovsky, D, Tuddenham, EGD. (eds) Postgraduate Haematology, 5th edn. Blackwell Publishing; 2005.Google Scholar
Lowenstein, L, Bramlage, CA. The bone marrow in pregnancy and the puerperium. Blood. 1957;12(3):261–77.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×