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Chapter 21 - Trophoblast biology and early pregnancy

Published online by Cambridge University Press:  05 October 2010

By
Peter R. Stone  and
Larry W. Chamley
Edited by
Roy G. Farquharson  and
Mary D. Stephenson
Roy G. Farquharson
Affiliation:
University of Liverpool
Mary D. Stephenson
Affiliation:
University of Chicago
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Summary

This chapter examines the role of the unique cells of the placenta, the trophoblast, in the establishment of the placenta. It discusses the changes trophoblasts induce in the uterine environment. Recent evidence suggests that premature exposure of the placenta to maternal blood is likely to result in miscarriage. Subcellular trophoblast micro and/or nano particles are found in the maternal blood in both normal and pre eclamptic pregnancies with possibly increased quantities in pre-eclampsia. Deported trophoblasts may play a key role in the success of pregnancy via their effects on the maternal immune system. Antiphospholipid antibodies (aPL) are associated with thrombotic disease of the systemic circulation and were originally thought to induce recurrent miscarriage by causing thrombosis of the spiral arteries with subsequent infarction of the regions of the placenta supplied by the affected vessels. Heparin and aspirin therapy was introduced for women with recurrent miscarriage and aPL.

Keywords

air travelearly pregnancyfatal eventsrisk factorvenous thromboembolismpulmonary embolismlow molecular weight heparinpharmacological thromboprophylaxis
Type
Chapter
Information
Early Pregnancy , pp. 227 - 236
Publisher: Cambridge University Press
Print publication year: 2010

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