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Chapter 16 - Tests of Neuromuscular Transmission

Published online by Cambridge University Press:  14 September 2023

John A. Jarratt
John A. Jarratt
Affiliation:
Emeritus, Sheffield Teaching Hospitals NHS Foundation Trust
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Summary

Clinical examples of normal results obtained during repetitive nerve stimulation are given. These are followed by illustrations of the findings obtained from patients with myasthenia gravis or myasthenic syndrome. The different underlying pathophysiologies are discussed. A clinical case of pseudofacilitation is also included. The principles underlying the technique of voluntary single-fibre electromyography are described. Diagrams are also included to show how jitter measurements are made and how these are increased in neuromuscular transmission disorders. In severe cases transmission may fail, so-called blocking. Good clinical examples are included of normal jitter and of increased jitter with blocking.

Keywords

Repetitive Nerve Stimulation (RNS)Myasthenia GravisMyasthenic Syndrome (Lambert–Eaton Myasthenic Syndrome LEMS)Single-Fibre Electromyography (SFEMG)JitterBlocking
Type
Chapter
Information
Essential Electromyography , pp. 72 - 81
Publisher: Cambridge University Press
Print publication year: 2023

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