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Chapter 5 - Environmental Effects on Lung Morphogenesis and Function:

Tobacco Products, Combustion Products, and Other Sources of Pollution

Published online by Cambridge University Press:  05 April 2016

By
Cindy T. McEvoy  and
Eliot R. Spindel
Edited by
Alan H. Jobe ,
Jeffrey A. Whitsett  and
Steven H. Abman
Alan H. Jobe
Affiliation:
University of Cincinnati
Jeffrey A. Whitsett
Affiliation:
Cincinnati Children’s Hospital
Steven H. Abman
Affiliation:
University of Colorado School of Medicine
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Summary

Abstract

The fetal and neonatal lung are very sensitive to environmental conditions, which can alter lung development, leading to reduced lung function and increased risk of respiratory illness later in life. This is magnified in that the human lung primarily develops during prenatal life and infancy, after which it increases in size but not complexity. Therefore, early life events can lead to permanent structural changes that translate into lifelong alterations in pulmonary function with increased risk of respiratory disease and, potentially, earlier deterioration of lung function during the normal aging process. The effect of these exposures is dependent on individual susceptibilities, particularly genetic polymorphism and epigenetic changes, as well as the timing, duration, and level of exposures. In utero and early postnatal environmental factors that have been linked to changes in lung development include maternal use of tobacco products during pregnancy, secondhand tobacco smoke exposure, nicotine, and environmental pollution including air pollution and indoor wood-/cookstove exposures. This chapter will focus on how these exposures lead to altered lung morphology and the resulting clinical consequences with particular focus on the effects of in utero tobacco product exposure. Future environmental trends likely to influence lung development include e-cigarette usage and climate change.

Type
Chapter
Information
Fetal and Neonatal Lung Development
Clinical Correlates and Technologies for the Future
 , pp. 77 - 93
Publisher: Cambridge University Press
Print publication year: 2016

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References

Hislop, AA. Airway and blood vessel interaction during lung development. J Anat. 2002;201:325–334.CrossRefGoogle ScholarPubMed
Merkus, PJ, Ten Have-Opbroek, AA, Quanjer, PH. Human lung growth: a review. Pediatr Pulmonol. 1996;21:383–397.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Salihu, HM, Aliyu, MH, Pierre-Louis, BJ, Alexander, GR. Levels of excess infant deaths attributable to maternal smoking during pregnancy in the United States. Matern Child Health J. 2003;7:219–227.CrossRefGoogle ScholarPubMed
Dietz, PM, England, LJ, Shapiro-Mendoza, CK, Tong, VT, Farr, SL, Callaghan, WM. Infant morbidity and mortality attributable to prenatal smoking in the U.S. Am J Prev Med. 2010;39:45–52.CrossRefGoogle ScholarPubMed
U.S. Department of Health and Human Services. The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General – Executive Summary. 1–27. 2006. Atlanta, GA: Centers for Disease Control and Prevention.Google Scholar
Best, D. From the American Academy of Pediatrics: Technical report–Secondhand and prenatal tobacco smoke exposure. Pediatrics. 2009;124:e1017–e1044.CrossRefGoogle Scholar
Hayatbakhsh, MR, Sadasivam, S, Mamun, AA, Najman, JM, O'Callaghan, MJ. Maternal smoking during and after pregnancy and lung function in early adulthood: A prospective study. Thorax. 2009;64:810–814.CrossRefGoogle ScholarPubMed
Leung, GM, Ho, LM, Lam, TH. The economic burden of environmental tobacco smoke in the first year of life. Arch Dis Child. 2003;88:767–771.CrossRefGoogle ScholarPubMed
Stoddard, JJ, Gray, B. Maternal smoking and medical expenditures for childhood respiratory illness. Am J Public Health. 1997;87:205–209.CrossRefGoogle ScholarPubMed
Tager, IB, Weiss, ST, Munoz, A, Rosner, B, Speizer, FE. Longitudinal study of the effects of maternal smoking on pulmonary function in children. NEJM. 1983;309:699–703.CrossRefGoogle ScholarPubMed
Brown, RW, Hanrahan, JP, Castile, RG, Tager, IB. Effect of maternal smoking during pregnancy on passive respiratory mechanics in early infancy. Pediatr Pulmonol. 1995;19:23–28.CrossRefGoogle ScholarPubMed
Stick, SM, Burton, PR, Gurrin, L, Sly, PD, LeSouef, PN. Effects of maternal smoking during pregnancy and a family history of asthma on respiratory function in newborn infants. Lancet. 1996;348:1060–1064.CrossRefGoogle Scholar
Lodrup Carlsen, KC, Jaakkola, JJ, Nafstad, P, Carlsen, KH. In utero exposure to cigarette smoking influences lung function at birth. Eur Respir J. 1997;10:1774–1779.CrossRefGoogle ScholarPubMed
Li, YF, Gilliland, FD, Berhane, K, McConnell, R, Gauderman, WJ, Rappaport, EB, et al. Effects of in utero and environmental tobacco smoke exposure on lung function in boys and girls with and without asthma. Am J Respir Crit Care Med. 2000;162:2097–2104.CrossRefGoogle ScholarPubMed
Hanrahan, JP, Tager, IB, Segal, MR, Tosteson, TD, Castile, RG, Van Vunakis, H, et al. The effect of maternal smoking during pregnancy on early infant lung function. Am Rev Respir Dis. 1992;145:1129–1135.CrossRefGoogle ScholarPubMed
Centers for Disease Control and Prevention. Cigarette use among high school students–United States, 1991–2007. Morb Mortal Wkly Rep. 2008;57:686–688.Google Scholar
Hoo, AF, Henschen, M, Dezateux, C, Costeloe, K, Stocks, J. Respiratory function among preterm infants whose mothers smoked during pregnancy. Am J Respir Crit Care Med. 1998;158:700–705.CrossRefGoogle ScholarPubMed
Cunningham, J, Dockery, DW, Speizer, FE. Maternal smoking during pregnancy as a predictor of lung function in children. Am J Epidemiol. 1994;139:1139–1152.CrossRefGoogle ScholarPubMed
Talhout, R, Schulz, T, Florek, E, van BJ, Wester, P, Opperhuizen, A. Hazardous compounds in tobacco smoke. Int J Environ Res Public Health. 2011;8:613–628.CrossRefGoogle ScholarPubMed
Hecht, SS. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst. 1999;91:1194–1210.CrossRefGoogle ScholarPubMed
Collins, MH, Moessinger, AC, Kleinerman, J, Bassi, J, Rosso, P, Collins, AM, et al. Fetal lung hypoplasia associated with maternal smoking: a morphometric analysis. Pediatr Res. 1985;19:408–412.CrossRefGoogle ScholarPubMed
Maritz, GS, Dennis, H. Maternal nicotine exposure during gestation and lactation interferes with alveolar development in the neonatal lung. Reprod Fertil Dev. 1998;10:255–261.CrossRefGoogle ScholarPubMed
Maritz, GS. Maternal nicotine exposure during gestation and lactation of rats induce microscopic emphysema in the offspring. Exp Lung Res. 2002;28:391–403.CrossRefGoogle ScholarPubMed
Maritz, GS, Woolward, K. Effect of maternal nicotine exposure on neonatal lung elastic tissue and possible consequences. S Afr Med J. 1992;81:517–519.Google ScholarPubMed
Sekhon, HS, Jia, Y, Raab, R, Kuryatov, A, Pankow, JF, Whitsett, JA, et al. Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys. J Clin Invest. 1999;103:637–647.CrossRefGoogle ScholarPubMed
Proskocil, BJ, Sekhon, HS, Jia, Y, Savchenko, V, Blakely, RD, Lindstrom, J, et al. Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Endocrinology. 2004;145:2498–2506.CrossRefGoogle ScholarPubMed
Papke, RL. Merging old and new perspectives on nicotinic acetylcholine receptors. Biochem Pharmacol. 2014;89:1–11.CrossRefGoogle ScholarPubMed
Hurst, R, Rollema, H, Bertrand, D. Nicotinic acetylcholine receptors: from basic science to therapeutics. Pharmacol Ther. 2013;137:22–54.CrossRefGoogle ScholarPubMed
Kabbani, N, Nordman, JC, Corgiat, BA, Veltri, DP, Shehu, A, Seymour, VA, et al. Are nicotinic acetylcholine receptors coupled to G proteins? Bioessays. 2013;35:1025–1034.CrossRefGoogle ScholarPubMed
Sekhon, HS, Keller, JA, Proskocil, BJ, Martin, EL, Spindel, ER. Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors. Am J Respir Cell Mol Biol. 2002;26:31–41.CrossRefGoogle ScholarPubMed
Sekhon, HS, Proskocil, BJ, Clark, JA, Spindel, ER. Prenatal nicotine exposure increases connective tissue expression in foetal monkey pulmonary vessels. Eur Respir J. 2004;23:906–915.CrossRefGoogle ScholarPubMed
Sekhon, HS, Keller, JA, Benowitz, NL, Spindel, ER. Prenatal nicotine exposure alters pulmonary function in newborn rhesus monkeys. Am J Respir Crit Care Med. 2001;164:989–994.CrossRefGoogle ScholarPubMed
Wongtrakool, C, Roser-Page, S, Rivera, HN, Roman, J. Nicotine alters lung branching morphogenesis through the alpha7 nicotinic acetylcholine receptor. Am J Physiol Lung Cell Mol Physiol. 2007;293:L611–L618.CrossRefGoogle ScholarPubMed
Wongtrakool, C, Wang, N, Hyde, DM, Roman, J, Spindel, ER. Prenatal nicotine exposure alters lung function and airway geometry through alpha7 nicotinic receptors. Am J Respir Cell Mol Biol. 2012;46:695–702.CrossRefGoogle ScholarPubMed
Ten Have-Opbroek, AA. The development of the lung in mammals: an analysis of concepts and findings. Am J Anat. 1981;162:201–219.CrossRefGoogle ScholarPubMed
Rantakallio, P. Relationship of maternal smoking to morbidity and mortality of the child up to the age of five. Acta Paediatr Scand. 1978;67:621–631.CrossRefGoogle Scholar
Fergusson, DM, Horwood, LJ, Shannon, FT. Parental smoking and respiratory illness in infancy. Arch Dis Child. 1980;55:358–361.CrossRefGoogle ScholarPubMed
Taylor, B, Wadsworth, J. Maternal smoking during pregnancy and lower respiratory tract illness in early life. Arch Dis Child. 1987;62:786–791.CrossRefGoogle ScholarPubMed
Margolis, PA, Keyes, LL, Greenberg, RA, Bauman, KE, LaVange, LM. Urinary cotinine and parent history (questionnaire) as indicators of passive smoking and predictors of lower respiratory illness in infants. Pediatr Pulmonol. 1997;23:417–423.3.0.CO;2-F>CrossRefGoogle ScholarPubMed
Tager, IB, Hanrahan, JP, Tosteson, TD, Castile, RG, Brown, RW, Weiss, ST, et al. Lung function, pre- and post-natal smoke exposure, and wheezing in the first year of life. Am Rev Respir Dis. 1993;147:811–817.CrossRefGoogle ScholarPubMed
Hu, FB, Persky, V, Flay, BR, Zelli, A, Cooksey, J, Richardson, J. Prevalence of asthma and wheezing in public schoolchildren: association with maternal smoking during pregnancy. Ann Allergy Asthma Immunol. 1997;79:80–84.CrossRefGoogle ScholarPubMed
Zlotkowska, R, Zejda, JE. Fetal and postnatal exposure to tobacco smoke and respiratory health in children. Eur J Epidemiol. 2005;20:719–727.CrossRefGoogle ScholarPubMed
Lannero, E, Pershagen, G, Wickman, M, Nordvall, L. Maternal smoking during pregnancy increases the risk of recurrent wheezing during the first years of life (BAMSE). Respir Res. 2006;7:3.CrossRefGoogle ScholarPubMed
Alati, R, Al, MA, O'Callaghan, M, Najman, JM, Williams, GM. In utero and postnatal maternal smoking and asthma in adolescence. Epidemiology. 2006;17:138–144.CrossRefGoogle ScholarPubMed
Bjerg, A, Hedman, L, Perzanowski, M, Lundback, B, Ronmark, E. A strong synergism of low birth weight and prenatal smoking on asthma in schoolchildren. Pediatrics. 2011;127:e905–e912.CrossRefGoogle Scholar
Pattenden, S, Antova, T, Neuberger, M, Nikiforov, B, De, SM, Grize, L, et al. Parental smoking and children's respiratory health: independent effects of prenatal and postnatal exposure. Tob Control. 2006;15:294–301.CrossRefGoogle ScholarPubMed
Burke, H, Leonardi-Bee, J, Hashim, A, Pine-Abata, H, Chen, Y, Cook, DG, et al. Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and meta-analysis. Pediatrics. 2012;129:735–744.CrossRefGoogle ScholarPubMed
Neuman, A, Hohmann, C, Orsini, N, Pershagen, G, Eller, E, Kjaer, HF, et al. Maternal smoking in pregnancy and asthma in preschool children: a pooled analysis of eight birth cohorts. Am J Respir Crit Care Med. 2012; 186:1037–1043.CrossRefGoogle ScholarPubMed
Adler, A, Tager, IB, Brown, RW, Ngo, L, Hanrahan, JP. Relationship between an index of tidal flow and lower respiratory illness in the first year of life. Pediatr Pulmonol. 1995;20:137–144.CrossRefGoogle ScholarPubMed
Martinez, FD, Morgan, WJ, Wright, AL, Holberg, CJ, Taussig, LM. Diminished lung function as a predisposing factor for wheezing respiratory illness in infants. New Engl J Med. 1988;319:1112–1117.CrossRefGoogle ScholarPubMed
Dezateux, C, Stocks, J, Dundas, I, Fletcher, ME. Impaired airway function and wheezing in infancy. The influence of maternal smoking and a genetic predisposition to asthma. Am J Respir Crit Care Med. 1999;159:403–410.CrossRefGoogle Scholar
Haland, G, Carlsen, KC, Sandvik, L, Devulapalli, CS, Munthe-Kaas, MC, Pettersen, M, et al. Reduced lung function at birth and the risk of asthma at 10 years of age. N Engl J Med. 2006;355:1682–1689.CrossRefGoogle Scholar
Yuksel, B, Greenough, A, Giffin, F, Nicolaides, KH. Tidal breathing parameters in the first week of life and subsequent cough and wheeze. Thorax. 1996;51:815–818.CrossRefGoogle ScholarPubMed
Young, S, Arnott, J, O'Keeffe, PT, Le Souef, PN, Landau, LI. The association between early life lung function and wheezing during the first 2 yrs of life. Eur Respir J. 2000;15:151–157.CrossRefGoogle ScholarPubMed
Martinez, FD. The origins of asthma and chronic obstructive pulmonary disease in early life. Proc Am Thorac Soc. 2009;6:272–277.CrossRefGoogle ScholarPubMed
Turner, SW, Palmer, LJ, Rye, PJ, Gibson, NA, Judge, PK, Cox, M, et al. The relationship between infant airway function, childhood airway responsiveness, and asthma. Am J Respir Crit Care Med. 2004;169:921–927.CrossRefGoogle ScholarPubMed
Holberg, CJ, Wright, AL, Martinez, FD, Morgan, WJ, Taussig, LM. Child day care, smoking by caregivers, and lower respiratory tract illness in the first 3 years of life. Pediatrics. 1993;91:885–892.CrossRefGoogle ScholarPubMed
McEvoy, CT, Schilling, D, Clay, N, Jackson, K, Go, MD, Spitale, P, et al. Vitamin C supplementation for pregnant smoking women and pulmonary function in their newborn infants: a randomized clinical trial. JAMA. 2014;311:2074–2082.CrossRefGoogle ScholarPubMed
Coleman, T, Chamberlain, C, Davey, MA, Cooper, SE, Leonardi-Bee, J. Pharmacological interventions for promoting smoking cessation during pregnancy. Cochrane Database Syst Rev. 2012;9:CD010078.Google Scholar
Joya, X, Manzano, C, Alvarez, AT, Mercadal, M, Torres, F, Salat-Batlle, J, et al. Transgenerational exposure to environmental tobacco smoke. Int J Environ Res Public Health. 2014;11:7261–7274.CrossRefGoogle ScholarPubMed
Nieuwenhuijsen, MJ, Dadvand, P, Grellier, J, Martinez, D, Vrijheid, M. Environmental risk factors of pregnancy outcomes: a summary of recent meta-analyses of epidemiological studies. Environ Health. 2013;12:6.CrossRefGoogle ScholarPubMed
Simons, E, To, T, Moineddin, R, Stieb, D, Dell, SD. Maternal second-hand smoke exposure in pregnancy is associated with childhood asthma development. J Allergy Clin Immunol Pract. 2014;2:201–207.CrossRefGoogle ScholarPubMed
Joad, JP, Ji, C, Kott, KS, Bric, JM, Pinkerton, KE. In utero and postnatal effects of sidestream cigarette smoke exposure on lung function, hyperresponsiveness, and neuroendocrine cells in rats. Toxicol Appl Pharmacol. 1995;132:63–71.CrossRefGoogle ScholarPubMed
Joad, JP, Kott, KS, Bric, JM, Peake, JL, Pinkerton, KE. Effect of perinatal secondhand tobacco smoke exposure on in vivo and intrinsic airway structure/function in non-human primates. Toxicol Appl Pharmacol. 2009;234:339–344.CrossRefGoogle ScholarPubMed
Goniewicz, ML, Knysak, J, Gawron, M, Kosmider, L, Sobczak, A, Kurek, J, et al. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control. 2014;23:133–139.CrossRefGoogle ScholarPubMed
Cheng, T. Chemical evaluation of electronic cigarettes. Tob Control. 2014;23(Suppl 2):ii11–ii17.CrossRefGoogle ScholarPubMed
Kosmider, L, Sobczak, A, Fik, M, Knysak, J, Zaciera, M, Kurek, J, et al. Carbonyl compounds in electronic cigarette vapors – effects of nicotine solvent and battery output voltage. Nicotine Tob Res. 2014.CrossRefGoogle Scholar
Uchiyama, S, Ohta, K, Inaba, Y, Kunugita, N. Determination of carbonyl compounds generated from the E-cigarette using coupled silica cartridges impregnated with hydroquinone and 2,4-dinitrophenylhydrazine, followed by high-performance liquid chromatography. Anal Sci. 2013;29:1219–1222.CrossRefGoogle ScholarPubMed
Etter, JF. Levels of saliva cotinine in electronic cigarette users. Addiction. 2014;109:825–829.CrossRefGoogle ScholarPubMed
Schroeder, MJ, Hoffman, AC. Electronic cigarettes and nicotine clinical pharmacology. Tob Control. 2014;23(Suppl 2):ii30–ii35.CrossRefGoogle ScholarPubMed
Flouris, AD, Chorti, MS, Poulianiti, KP, Jamurtas, AZ, Kostikas, K, Tzatzarakis, MN, et al. Acute impact of active and passive electronic cigarette smoking on serum cotinine and lung function. Inhal Toxicol. 2013;25:91–101.CrossRefGoogle ScholarPubMed
Dutra, LM, Glantz, SA. Electronic cigarettes and conventional cigarette use among US adolescents: a cross-sectional study. JAMA Pediatr. 2014.CrossRefGoogle Scholar
Kmietowicz, Z. E-cigarettes are "gateway devices" for smoking among young people, say researchers. BMJ. 2014;348:g2034.CrossRefGoogle ScholarPubMed
Edwards, R, Carter, K, Peace, J, Blakely, T. An examination of smoking initiation rates by age: results from a large longitudinal study in New Zealand. Aust N Z J Public Health. 2013;37:516–519.CrossRefGoogle ScholarPubMed
Breslau, N, Peterson, EL. Smoking cessation in young adults: age at initiation of cigarette smoking and other suspected influences. Am J Public Health. 1996;86:214–220.CrossRefGoogle ScholarPubMed
Graf, N, Johansen, P, Schindler, C, Wuthrich, B, Ackermann-Liebrich, U, Gassner, M, et al. Analysis of the relationship between pollinosis and date of birth in Switzerland. Int Arch Allergy Immunol. 2007;143:269–275.CrossRefGoogle ScholarPubMed
Fedulov, AV, Leme, A, Yang, Z, Dahl, M, Lim, R, Mariani, TJ, et al. Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility. Am J Respir Cell Mol Biol. 2008;38:57–67.CrossRefGoogle ScholarPubMed
Kajekar, R. Environmental factors and developmental outcomes in the lung. Pharmacol Ther. 2007;114:129–145.CrossRefGoogle ScholarPubMed
Wang, L, Pinkerton, KE. Air pollutant effects on fetal and early postnatal development. Birth Defects Res C Embryo Today. 2007;81:144–154.CrossRefGoogle ScholarPubMed
Pereira, G, Belanger, K, Ebisu, K, Bell, ML. Fine particulate matter and risk of preterm birth in Connecticut in 2000–2006: a longitudinal study. Am J Epidemiol. 2014;179:67–74.CrossRefGoogle ScholarPubMed
Bobak, M. Outdoor air pollution, low birth weight, and prematurity. Environ Health Perspect. 2000;108:173–176.CrossRefGoogle ScholarPubMed
Shah, PS, Balkhair, T. Air pollution and birth outcomes: a systematic review. Environ Int. 2011;37:498–516.CrossRefGoogle ScholarPubMed
Proietti, E, Roosli, M, Frey, U, Latzin, P. Air pollution during pregnancy and neonatal outcome: a review. J Aerosol Med Pulm Drug Deliv. 2013;26:9–23.CrossRefGoogle ScholarPubMed
Jedrychowski, WA, Perera, FP, Maugeri, U, Mroz, E, Klimaszewska-Rembiasz, M, Flak, E, et al. Effect of prenatal exposure to fine particulate matter on ventilatory lung function of preschool children of non–smoking mothers. Paediatr Perinat Epidemiol. 2010;24:492–501.CrossRefGoogle ScholarPubMed
Jedrychowski, WA, Perera, FP, Maugeri, U, Mrozek-Budzyn, D, Mroz, E, Klimaszewska-Rembiasz, M, et al. Intrauterine exposure to polycyclic aromatic hydrocarbons, fine particulate matter and early wheeze. Prospective birth cohort study in 4-year olds. Pediatr Allergy Immunol. 2010;21:e723–e732.CrossRefGoogle Scholar
Mortimer, K, Neugebauer, R, Lurmann, F, Alcorn, S, Balmes, J, Tager, I. Air pollution and pulmonary function in asthmatic children: effects of prenatal and lifetime exposures. Epidemiology. 2008;19:550–557.CrossRefGoogle ScholarPubMed
Mortimer, K, Neugebauer, R, Lurmann, F, Alcorn, S, Balmes, J, Tager, I. Early-lifetime exposure to air pollution and allergic sensitization in children with asthma. J Asthma. 2008;45:874–881.CrossRefGoogle ScholarPubMed
Clark, NA, Demers, PA, Karr, CJ, Koehoorn, M, Lencar, C, Tamburic, L, et al. Effect of early life exposure to air pollution on development of childhood asthma. Environ Health Perspect. 2010;118:284–290.CrossRefGoogle ScholarPubMed
Fanucchi, MV, Plopper, CG, Evans, MJ, Hyde, DM, Van Winkle, LS, Gershwin, LJ, et al. Cyclic exposure to ozone alters distal airway development in infant rhesus monkeys. Am J Physiol Lung Cell Mol Physiol. 2006;291:L644–L650.CrossRefGoogle ScholarPubMed
Kajekar, R, Pieczarka, EM, Smiley-Jewell, SM, Schelegle, ES, Fanucchi, MV, Plopper, CG. Early postnatal exposure to allergen and ozone leads to hyperinnervation of the pulmonary epithelium. Respir Physiol Neurobiol. 2007;155:55–63.CrossRefGoogle ScholarPubMed
Miller, LA, Gerriets, JE, Tyler, NK, Abel, K, Schelegle, ES, Plopper, CG, et al. Ozone and allergen exposure during postnatal development alters the frequency and airway distribution of CD25+ cells in infant rhesus monkeys. Toxicol Appl Pharmacol. 2009;236:39–48.CrossRefGoogle ScholarPubMed
Clay, CC, Maniar-Hew, K, Gerriets, JE, Wang, TT, Postlethwait, EM, Evans, MJ, et al. Early life ozone exposure results in dysregulated innate immune function and altered microRNA expression in airway epithelium. PLoS One. 2014;9:e90401.CrossRefGoogle ScholarPubMed
Auten, RL, Gilmour, MI, Krantz, QT, Potts, EN, Mason, SN, Foster, WM. Maternal diesel inhalation increases airway hyperreactivity in ozone-exposed offspring. Am J Respir Cell Mol Biol. 2012;46:454–460.CrossRefGoogle ScholarPubMed
O'Brien, KL, Wolfson, LJ, Watt, JP, Henkle, E, Deloria-Knoll, M, McCall, N, et al. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet. 2009;374:893–902.CrossRefGoogle ScholarPubMed
Po, JY, FitzGerald, JM, Carlsten, C. Respiratory disease associated with solid biomass fuel exposure in rural women and children: systematic review and meta-analysis. Thorax. 2011;66:232–239.CrossRefGoogle ScholarPubMed
Eisner, MD, Anthonisen, N, Coultas, D, Kuenzli, N, Perez-Padilla, R, Postma, D, et al. An official American Thoracic Society public policy statement: novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010;182:693–718.CrossRefGoogle ScholarPubMed
Bruce, N, Perez-Padilla, R, Albalak, R. Indoor air pollution in developing countries: a major environmental and public health challenge. Bull World Health Organiz. 2000;78:1078–1092.Google Scholar
Mishra, V, Dai, X, Smith, KR, Mika, L. Maternal exposure to biomass smoke and reduced birth weight in Zimbabwe. Ann Epidemiol. 2004;14:740–747.CrossRefGoogle ScholarPubMed
Tielsch, JM, Katz, J, Thulasiraj, RD, Coles, CL, Sheeladevi, S, Yanik, EL, et al. Exposure to indoor biomass fuel and tobacco smoke and risk of adverse reproductive outcomes, mortality, respiratory morbidity and growth among newborn infants in south India. Int J Epidemiol. 2009;38:1351–1363.CrossRefGoogle ScholarPubMed
Mishra, V, Retherford, RD, Smith, KR. Cooking smoke and tobacco smoke as risk factors for stillbirth. Int J Environ Health Res. 2005;15:397–410.CrossRefGoogle ScholarPubMed
Mishra, V, Retherford, RD. Does biofuel smoke contribute to anaemia and stunting in early childhood? Int J Epidemiol. 2007;36:117–129.CrossRefGoogle ScholarPubMed
Dezateux, C, Lum, S, Hoo, AF, Hawdon, J, Costeloe, K, Stocks, J. Low birth weight for gestation and airway function in infancy: exploring the fetal origins hypothesis. Thorax. 2004;59:60–66.Google ScholarPubMed
Rona, RJ, Gulliford, MC, Chinn, S. Effects of prematurity and intrauterine growth on respiratory health and lung function in childhood. BMJ. 1993;306:817–820.CrossRefGoogle ScholarPubMed
Lawlor, DA, Ebrahim, S, Davey, SG. Association of birth weight with adult lung function: findings from the British Women's Heart and Health Study and a meta-analysis. Thorax. 2005;60:851–858.CrossRefGoogle ScholarPubMed
Kurmi, OP, Devereux, GS, Smith, WC, Semple, S, Steiner, MF, Simkhada, P, et al. Reduced lung function due to biomass smoke exposure in young adults in rural Nepal. Eur Respir J. 2013;41:25–30.CrossRefGoogle ScholarPubMed
Regalado, J, Perez-Padilla, R, Sansores, R, Paramo Ramirez, JI, Brauer, M, Pare, P, et al. The effect of biomass burning on respiratory symptoms and lung function in rural Mexican women. Am J Respir Crit Care Med. 2006;174:901–905.CrossRefGoogle ScholarPubMed
Churg, A, Brauer, M, del Carmen Avila-Casado, M, Fortoul, TI, Wright, JL. Chronic exposure to high levels of particulate air pollution and small airway remodeling. Environ Health Perspect. 2003;111:714–718.CrossRefGoogle ScholarPubMed
Romieu, I, Riojas-Rodriguez, H, Marron-Mares, AT, Schilmann, A, Perez-Padilla, R, Masera, O. Improved biomass stove intervention in rural Mexico: impact on the respiratory health of women. Am J Respir Crit Care Med. 2009;180:649–656.CrossRefGoogle ScholarPubMed
Adetona, O, Li, Z, Sjodin, A, Romanoff, LC, Aguilar-Villalobos, M, Needham, LL, et al. Biomonitoring of polycyclic aromatic hydrocarbon exposure in pregnant women in Trujillo, Peru–comparison of different fuel types used for cooking. Environ Int. 2013;53:1–8.CrossRefGoogle ScholarPubMed
Riojas-Rodriguez, H, Schilmann, A, Marron-Mares, AT, Masera, O, Li, Z, Romanoff, L, et al. Impact of the improved Patsari biomass stove on urinary polycyclic aromatic hydrocarbon biomarkers and carbon monoxide exposures in rural Mexican women. Environ Health Perspect. 2011;119:1301–1307.CrossRefGoogle ScholarPubMed
Danielsen, PH, Brauner, EV, Barregard, L, Sallsten, G, Wallin, M, Olinski, R, et al. Oxidatively damaged DNA and its repair after experimental exposure to wood smoke in healthy humans. Mutat Res. 2008;642:37–42.CrossRefGoogle ScholarPubMed
Kurmi, OP, Dunster, C, Ayres, JG, Kelly, FJ. Oxidative potential of smoke from burning wood and mixed biomass fuels. Free Radic Res. 2013;47:829–835.CrossRefGoogle ScholarPubMed
Unosson, J, Blomberg, A, Sandstrom, T, Muala, A, Boman, C, Nystrom, R, et al. Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans. Part Fibre Toxicol. 2013;10:20.CrossRefGoogle ScholarPubMed
Jensen, A, Karottki, DG, Christensen, JM, Bonlokke, JH, Sigsgaard, T, Glasius, M, et al. Biomarkers of oxidative stress and inflammation after wood smoke exposure in a reconstructed Viking Age house. Environ Mol Mutagen. 2014;55(8):652–661.CrossRefGoogle Scholar
Forchhammer, L, Moller, P, Riddervold, IS, Bonlokke, J, Massling, A, Sigsgaard, T, et al. Controlled human wood smoke exposure: oxidative stress, inflammation and microvascular function. Part Fibre Toxicol. 2012;9:7.CrossRefGoogle ScholarPubMed
Riddervold, IS, Bonlokke, JH, Olin, AC, Gronborg, TK, Schlunssen, V, Skogstrand, K, et al. Effects of wood smoke particles from wood-burning stoves on the respiratory health of atopic humans. Part Fibre Toxicol. 2012;9:12.CrossRefGoogle ScholarPubMed
Yang, IA, Fong, KM, Zimmerman, PV, Holgate, ST, Holloway, JW. Genetic susceptibility to the respiratory effects of air pollution. Postgrad Med J. 2009;85:428–436.Google Scholar
Bierut, LJ. Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25. Trends Pharmacol Sci. 2010;31:46–51.CrossRefGoogle ScholarPubMed
Leermakers, ET, Taal, HR, Bakker, R, Steegers, EA, Hofman, A, Jaddoe, VW. A common genetic variant at 15q25 modifies the associations of maternal smoking during pregnancy with fetal growth: the generation R study. PLoS One. 2012;7:e34584.CrossRefGoogle ScholarPubMed
Bolt, HM, Thier, R. Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology. Curr Drug Metab. 2006;7:613–628.CrossRefGoogle ScholarPubMed
Romieu, I, Ramirez-Aguilar, M, Sienra-Monge, JJ, Moreno-Macias, H, Del Rio-Navarro, BE, David, G, et al. GSTM1 and GSTP1 and respiratory health in asthmatic children exposed to ozone. Eur Respir J. 2006;28:953–959.CrossRefGoogle ScholarPubMed
Gilliland, FD, Li, YF, Dubeau, L, Berhane, K, Avol, E, McConnell, R, et al. Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med. 2002;166:457–463.CrossRefGoogle ScholarPubMed
Murdzoska, J, Devadason, SG, Khoo, SK, Landau, LI, Young, S, Goldblatt, J, et al. In utero smoke exposure and maternal and infant GST genes on airway responsiveness and lung function in infancy. Am J Respir Crit Care Med. 2010;181:64–71.CrossRefGoogle ScholarPubMed
Rehan, VK, Liu, J, Sakurai, R, Torday, JS. Perinatal nicotine-induced transgenerational asthma. Am J Physiol Lung Cell Mol Physiol. 2013;305:L501–L507.CrossRefGoogle ScholarPubMed
Breton, CV, Byun, HM, Wenten, M, Pan, F, Yang, A, Gilliland, FD. Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. Am J Respir Crit Care Med. 2009;180:462–467.CrossRefGoogle ScholarPubMed
Joubert, BR, Haberg, SE, Bell, DA, Nilsen, RM, Vollset, SE, Midttun, O, et al. Maternal smoking and DNA methylation in newborns: in utero effect or epigenetic inheritance? Cancer Epidemiol Biomarkers Prev. 2014;23:1007–1017.CrossRefGoogle ScholarPubMed
Pinkerton, KE, Rom, WN, Akpinar-Elci, M, Balmes, JR, Bayram, H, Brandli, O, et al. An official American Thoracic Society workshop report: climate change and human health. Proc Am Thorac Soc. 2012;9:3–8.CrossRefGoogle ScholarPubMed
Ayres, JG, Forsberg, B, Annesi-Maesano, I, Dey, R, Ebi, KL, Helms, PJ, et al. Climate change and respiratory disease: European Respiratory Society position statement. Eur Respir J. 2009;34:295–302.CrossRefGoogle ScholarPubMed
Rice, MB, Thurston, GD, Balmes, JR, Pinkerton, KE. Climate change. A global threat to cardiopulmonary health. Am J Respir Crit Care Med. 2014;189:512–519.CrossRefGoogle ScholarPubMed
Forsberg, B, Braback, L, Keune, H, Kobernus, M, Krayer von, KM, Yang, A, et al. An expert assessment on climate change and health – with a European focus on lungs and allergies. Environ Health. 2012;11(Suppl 1):S4.CrossRefGoogle ScholarPubMed

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