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Chapter 16 - Lung Growth Through the “Life Course” and Predictors and Determinants of Chronic Respiratory Disorders

Published online by Cambridge University Press:  05 April 2016

By
Fernando D. Martinez
Edited by
Alan H. Jobe ,
Jeffrey A. Whitsett  and
Steven H. Abman
Alan H. Jobe
Affiliation:
University of Cincinnati
Jeffrey A. Whitsett
Affiliation:
Cincinnati Children’s Hospital
Steven H. Abman
Affiliation:
University of Colorado School of Medicine
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Summary

Abstract

Strong observational and experimental evidence indicates that lung growth during fetal and early postnatal life is one of the strongest determinants of adult lung function. Genetic variation plays a critical role in determining maximal lung function reached in adult life. Factors that affect lung growth such as extreme prematurity with bronchopulmonary dysplasia, intrauterine growth retardation, exposure to tobacco smoke in utero and postnatally, and vitamin A and D deficiencies also play varying roles in determining lung function. However, catch-up growth seems to be able to reverse at least in part the negative effects of some of these conditions. Individuals who reach early adult life with lower levels of lung function are at increased risk of developing chronic obstructive pulmonary disease during the decline phase of lung function, after the third decade of life, and may also be more susceptible to the deleterious effects of active cigarette smoking.

Type
Chapter
Information
Fetal and Neonatal Lung Development
Clinical Correlates and Technologies for the Future
 , pp. 286 - 302
Publisher: Cambridge University Press
Print publication year: 2016

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