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Chapter 4 - Transcriptional Mechanisms Regulating Pulmonary Epithelial Maturation:

A Systems Biology Approach

Published online by Cambridge University Press:  05 April 2016

By
Jeffrey A. Whitsett  and
Yan Xu
Edited by
Alan H. Jobe ,
Jeffrey A. Whitsett  and
Steven H. Abman
Alan H. Jobe
Affiliation:
University of Cincinnati
Jeffrey A. Whitsett
Affiliation:
Cincinnati Children’s Hospital
Steven H. Abman
Affiliation:
University of Colorado School of Medicine
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Summary

Abstract

This chapter focuses on the perinatal period of lung growth and differentiation. Advances in high-resolution imaging are integrated with computational approaches to develop a “systems biology” approach to the study of perinatal lung development. Confocal microscopy, three-dimensional imaging, single-cell transcriptomics, and bioinformatics are providing deeper insights to the multiple cell types and molecular mechanisms controlling lung formation and function. Knowledge regarding the transcriptional and signaling networks at the single-cell level provide the framework to understand how cell–cell interactions are integrated to form and maintain the three-dimensional structure of the alveoli necessary for ventilation after birth.

Type
Chapter
Information
Fetal and Neonatal Lung Development
Clinical Correlates and Technologies for the Future
 , pp. 58 - 76
Publisher: Cambridge University Press
Print publication year: 2016

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